奈立索泮

奈立索泮名称

[ CAS 号 ]:
102771-12-0

[ 中文名 ]:
奈立索泮

[ 英文名 ]:
Nerisopam

[英文别名 ]:

奈立索泮物理化学性质

[ 密度 ]:
1.22g/cm3

[ 沸点 ]:
475.4ºC at 760mmHg

[ 分子式 ]:
C18H19N3O2

[ 分子量 ]:
309.36200

[ 闪点 ]:
241.3ºC

[ 精确质量 ]:
309.14800

[ PSA ]:
69.20000

[ LogP ]:
2.50780

[ 蒸汽压 ]:
3.34E-09mmHg at 25°C

[ 折射率 ]:
1.612

奈立索泮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE8746050
CHEMICAL NAME :
5H-2,3-Benzodiazepine, 1-(4-aminophenyl)-7,8-dimethoxy-4-methyl-
CAS REGISTRY NUMBER :
102771-12-0
LAST UPDATED :
199706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C18-H19-N3-O2
MOLECULAR WEIGHT :
309.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
128 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 39,894,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
108 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 39,894,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
275 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 39,894,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
182 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 39,894,1989

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