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S-乙基异硫脲氢溴酸盐

S-乙基异硫脲氢溴酸盐用途

S-EIT(氢溴酸盐)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

S-乙基异硫脲氢溴酸盐名称

[ CAS 号 ]:
1071-37-0

[ 中文名 ]:
S-乙基异硫脲氢溴酸盐

[ 英文名 ]:
Ethyl carbamimidothioate hydrobromide (1:1)

[中文别名 ]:

[英文别名 ]:

MFCD00012585
Ethiron
S-ethylisothiouronium hydrobromate
S-Ethylisothio Urea,Hydrobromide
Ethyl carbamimidothioate hydrobromide (1:1)
Ethiron bromide
USAF EL-18
S-ethylthiouronium bromide
2-Ethyl-2-isothiourea hydrobromide
S-Ethylisothiuronium bromide

S-乙基异硫脲氢溴酸盐生物活性

[ 描述 ]:

S-EIT(氢溴酸盐)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

EIT(S-乙基异硫脲)氢溴酸盐是二、型无的选择性抑制剂。伊朗伊斯兰共和国对脂多糖诱导的血浆 [氮氧化物]增加产生剂量依赖性和 > 95%的抑制。伊朗伊斯兰共和国的第50页值为 0.4毫克/千克用我-精氨酸(但不是天-精氨酸)预处理可防止死亡率,同时不影响二、型无依赖性没有的产生,表明毒性可能是由于抑制其他无亚型(内皮或神经元)之一 [1]。选择性编号II拮抗剂减弱但不阻断胎儿肺中剪切应力诱导的血管舒张。编号II活性的刺激(可能来自平滑肌细胞)在剪切应力诱导的肺血管舒张过程中部分促成了没有介导的聚乙烯吡咯烷酮(肺血管阻力)下降。在存在自动变速箱或另一种选择性 iNOS系统抑制剂秒-乙基异硫脲 (EIT)的情况下用同种异体抗原刺激的脾细胞比在没有 iNOS系统抑制剂的情况下刺激的细胞产生更多的白细胞介素 (IL)-4和 IL-10Th1型细胞因子白细胞介素2和干扰素 (IFN)-γ的产生并未因抑制没有合成而增强。急性给予 EIT(380 nmol/h)另一种诱导型一氧化氮合酶选择性抑制剂,也减弱了妊娠引起的肾小球滤过率和有效肾血浆流量的增加。

S-乙基异硫脲氢溴酸盐物理化学性质

[ 密度 ]:
1.19 g/cm3

[ 沸点 ]:
159.6ºC at 760 mmHg

[ 熔点 ]:
79-81°C

[ 分子式 ]:
C₃H₉BrN₂S

[ 分子量 ]:
185.09

[ 闪点 ]:
50.3ºC

[ 精确质量 ]:
183.966980

[ PSA ]:
75.17000

[ LogP ]:
2.39110

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
2.26mmHg at 25°C

[ 折射率 ]:
1.548

[ 储存条件 ]:
2-8°C

S-乙基异硫脲氢溴酸盐MSDS

详细MSDS(安全技术说明书)

S-乙基异硫脲氢溴酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UM6825000

CHEMICAL NAME :: Pseudourea, 2-ethyl-2-thio-, hydrobromide

CAS REGISTRY NUMBER :: 1071-37-0

LAST UPDATED :: 198706

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C3-H8-N2-S.Br-H

MOLECULAR WEIGHT :: 185.11

WISWESSER LINE NOTATION :: SHYZUN2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 94,1419,1974

S-乙基异硫脲氢溴酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UM6825000

[ 海关编码 ]:
2930909090

S-乙基异硫脲氢溴酸盐合成路线

详细合成路线

S-乙基异硫脲氢溴酸盐上下游产品

S-乙基异硫脲氢溴酸盐上游产品

S-乙基异硫脲氢溴酸盐下游产品

S-乙基异硫脲氢溴酸盐海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

S-乙基异硫脲氢溴酸盐文献

Differential activity of NO synthase inhibitors as chemopreventive agents in a primary rat tracheal epithelial cell transformation system.

Neoplasia 4(4) , 332-6, (2002)

A model to study the effectiveness of potential chemopreventive agents that inhibit neoplastic process by different mechanisms has been used to test the efficacy of seven nitric oxide synthase (NOS) i...

Inotropic response to endothelin-1, isoprenaline and calcium in cardiomyocytes isolated from endotoxin treated rats: effects of ethyl-isothiourea and dexamethasone.

Br. J. Pharmacol. 130(6) , 1275-82, (2000)

1. The contractile effects of endothelin-1, isoprenaline and extracellular calcium were assessed on ventricular cardiomyocytes isolated from lipopolysaccharide-treated rats. The involvement of nitric ...

Inducible nitric oxide synthase inhibition attenuates renal hemodynamics during pregnancy.

Hypertension 39(2 Pt 2) , 586-90, (2002)

Acute, nonselective nitric oxide synthase inhibition in the pregnant rat decreases glomerular filtration rate and renal plasma flow, suggesting a role for nitric oxide in mediating renal vasodilation ...

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