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表告依春

表告依春用途

Epigoitrin 是板蓝根中的一种的天然生物碱,具有抗病毒活性。Epigoitrin 能通过线粒体抗病毒信号降低对流感病毒的易感性。

表告依春名称

[ CAS 号 ]:
1072-93-1

[ 中文名 ]:
表告依春

[ 英文名 ]:
Epigoitrin

[中文别名 ]:

[英文别名 ]:

5-vinyloxazolidin-2-thione
Goitrin
Epigoitrin
5-vinyl-2-oxazolidinethione
Goitrine Epigoitrin
(5R)-5-Vinyl-1,3-oxazolidine-2-thione
2-Oxazolidinethione, 5-ethenyl-, (5R)-
(R)-5-Ethenyl-2-oxazolidinethione
goitrin, (±)-isomer
R-5-vinyl-2-thiooxazolidone

表告依春生物活性

[ 描述 ]:

Epigoitrin 是板蓝根中的一种的天然生物碱,具有抗病毒活性。Epigoitrin 能通过线粒体抗病毒信号降低对流感病毒的易感性。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

[参考文献]

[1]. Luo Z, et al. Epigoitrin, an Alkaloid From Isatis indigotica, Reduces H1N1 Infection in Stress-Induced Susceptible Model in vivo and in vitro. Front Pharmacol. 2019 Feb 7;10:78.

[2]. Xiao P, et al. Antiviral activities against influenza virus (FM1) of bioactive fractions and representative compounds extracted from Banlangen (Radix Isatidis). J Tradit Chin Med. 2016 Jun;36(3):369-76.

表告依春物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
150.6±43.0 °C at 760 mmHg

[ 熔点 ]:
50ºC

[ 分子式 ]:
C₅H₇NOS

[ 分子量 ]:
129.180

[ 闪点 ]:
44.9±28.2 °C

[ 精确质量 ]:
129.024841

[ PSA ]:
53.35000

[ LogP ]:
0.38

[ 外观性状 ]:
solid

[ 蒸汽压 ]:
3.8±0.3 mmHg at 25°C

[ 折射率 ]:
1.570

[ 储存条件 ]:
2~8°C，干燥

表告依春毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ2280000

CHEMICAL NAME :: 2-Oxazolidinethione, 5-vinyl-, (R)-

CAS REGISTRY NUMBER :: 1072-93-1

LAST UPDATED :: 199403

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H7-N-O-S

MOLECULAR WEIGHT :: 129.19

WISWESSER LINE NOTATION :: T5MYOTJ BUS D1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 17,483,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 120 mg/kg/4D-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in thyroid weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,279,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 mg/kg

SEX/DURATION :: female 8-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 18,159,1980

表告依春安全信息

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
24/25

[ 海关编码 ]:
2934999090

表告依春海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%