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Illudin S

Illudin S用途

Illudin S 是一种倍半萜烯毒素,具有强抗肿瘤和抗病毒活性。Illudin S 具有基因毒性活性。

Illudin S名称

[ CAS 号 ]:
1149-99-1

[ 中文名 ]:
隐陡头菌素S

[ 英文名 ]:
Illudin S

[英文别名 ]:

Lampterol
Illusin S

Illudin S生物活性

[ 描述 ]:

Illudin S 是一种倍半萜烯毒素,具有强抗肿瘤和抗病毒活性。Illudin S 具有基因毒性活性。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 细胞周期/DNA损伤 >> DNA烷基化剂/交联剂

[体外研究]

Illudin S(0-0.26nm；24-72小时)对人成纤维细胞具有细胞毒性[2]。细胞活力测定[2]细胞系：人成纤维细胞浓度：0-0.26nm培养时间：24小时,72小时结果：细胞存活率降低。

[参考文献]

[1]. Hansruedi Glatt, et al. Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells. Arch Toxicol . 2014 Jan;88(1):161-9.

[2]. Nicolaas G J Jaspers, et al. Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair (Amst). 2002 Dec 5;1(12):1027-38.

[3]. Illudin S, the sole antiviral compound in mature fruiting bodies of Omphalotus illudens

Illudin S物理化学性质

[ 密度 ]:
1.34g/cm3

[ 沸点 ]:
509.6ºC at 760mmHg

[ 分子式 ]:
C₁₅H₂₀O₄

[ 分子量 ]:
264.31700

[ 闪点 ]:
276.1ºC

[ 精确质量 ]:
264.13600

[ PSA ]:
77.76000

[ LogP ]:
0.71630

[ 蒸汽压 ]:
1.61E-12mmHg at 25°C

[ 折射率 ]:
1.619

Illudin S毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH0204300

CHEMICAL NAME :: Sprio(cyclopropane-1,5'-(5H)inden)-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2'-(hydroxy methyl)-2',4',6'-trimethyl-, (2'S,3'R,6'R)-

CAS REGISTRY NUMBER :: 1149-99-1

BEILSTEIN REFERENCE NO. :: 2336420

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C15-H20-O4

MOLECULAR WEIGHT :: 264.35

WISWESSER LINE NOTATION :: L56 FV HXTJ BQ C1Q C1 GQ G1 I1 H-& AL3XTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 15600 ng/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 215,179,1989

Illudin S

Illudin S用途

Illudin S名称

Illudin S生物活性

Illudin S物理化学性质

Illudin S毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Illudin S合成路线

详细合成路线

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