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甲乙双酮

甲乙双酮用途

Parametadione(异噻二酮)是一种抗癫痫药物[1]。

甲乙双酮名称

[ CAS 号 ]:
115-67-3

[ 中文名 ]:
甲乙双酮

[ 英文名 ]:
paramethadione (500 mg)

[英文别名 ]:

Parametadione [DCIT]
5-ethyl-3,5-dimethyl-oxazolidine-2,4-dione
Paramethadionum
Parametadiona
Parametadione
5-Ethyl-3,5-dimethyloxazolidine-2,4-dione
Paramethadion
Parametadiona [INN-Spanish]
Isoethadione
Paramethadionum [INN-Latin]

甲乙双酮生物活性

[ 描述 ]:

Parametadione(异噻二酮)是一种抗癫痫药物[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Iravani J. Die Wirkung einiger zentral wirksamer Pharmaka auf die synaptische Ubertragung im Krebsmuskel [The effect of some centrally acting drugs on the synaptic transmission in the crayfish muscle]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Aug 20;251(4):375-95.

甲乙双酮物理化学性质

[ 密度 ]:
d425 1.1180-1.1240

[ 沸点 ]:
281.82°C (rough estimate)

[ 分子式 ]:
C₇H₁₁NO₃

[ 分子量 ]:
157.16700

[ 精确质量 ]:
157.07400

[ PSA ]:
46.61000

[ LogP ]:
0.70160

[ 折射率 ]:
nD25 1.449

甲乙双酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RP9800000

CHEMICAL NAME :: 2,4-Oxazolidinedione, 5-ethyl-3,5-dimethyl-

CAS REGISTRY NUMBER :: 115-67-3

BEILSTEIN REFERENCE NO. :: 0127715

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C7-H11-N-O3

MOLECULAR WEIGHT :: 157.19

WISWESSER LINE NOTATION :: T5OVNV EHJ C1 E2 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,280,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,280,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2640 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 37,126,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2640 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - homeostasis

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 37,126,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 1273 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 38,438,1979 *** REVIEWS *** TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965

甲乙双酮安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

甲乙双酮合成路线

详细合成路线

甲乙双酮上下游产品

甲乙双酮上游产品

甲乙双酮下游产品

甲乙双酮海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%