ASP-ALA-PHE-VAL-Β-ALA-LEU-MET-NH2

ASP-ALA-PHE-VAL-Β-ALA-LEU-MET-NH2用途

(β-Ala8)-神经激肽A(4-10)是一种神经肽,是一种有效且选择性的NK-2速激肽受体(神经激肽受体)激动剂[1]。

ASP-ALA-PHE-VAL-Β-ALA-LEU-MET-NH2名称

[ CAS 号 ]:
127633-71-0

[ 中文名 ]:
ASP-ALA-PHE-VAL-Β-ALA-LEU-MET-NH2

[ 英文名 ]:
(β-Ala8)-Neurokinin A (4-10)

[中文别名 ]:

[英文别名 ]:

Asp-Ala-Phe-Val-|A-Ala-Leu-Met-NH2
[Ala5,|A-Ala8]-|A-Neurokinin Fragment 4-10

ASP-ALA-PHE-VAL-Β-ALA-LEU-MET-NH2生物活性

[ 描述 ]:

(β-Ala8)-神经激肽A(4-10)是一种神经肽,是一种有效且选择性的NK-2速激肽受体(神经激肽受体)激动剂[1]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 神经激肽受体

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体

[体内研究]

(β-Ala8)-神经激肽A(4-10)(2μg/kg；静脉注射)增加清醒雌性狗的结肠张力[2]。

[参考文献]

[1]. C A Maggi, et al. In vivo pharmacology of [beta Ala8]neurokinin A-(4-10), a selective NK-2 tachykinin receptor agonist. Eur J Pharmacol. 1990 Feb 20;177(1-2):81-6.

[2]. G Basilisco, et al. A selective NK-2 antagonist blocks the increase of canine colonic tone and ileal contractions induced by the NK-2 selective receptor agonist, [beta Ala8] neurokinin A-(4-10). Aliment Pharmacol Ther. 1994 Oct;8(5):527-33.

ASP-ALA-PHE-VAL-Β-ALA-LEU-MET-NH2物理化学性质

[ 分子式 ]:
C₃₅H₅₆N₈O₉S

[ 分子量 ]:
764.93200

[ 精确质量 ]:
764.38900

[ PSA ]:
306.31000

[ LogP ]:
2.66780

ASP-ALA-PHE-VAL-Β-ALA-LEU-MET-NH2MSDS

详细MSDS(安全技术说明书)

ASP-ALA-PHE-VAL-Β-ALA-LEU-MET-NH2安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

ASP-ALA-PHE-VAL-Β-ALA-LEU-MET-NH2文献

Analogs of neurokinin A(4-10) afford protection against gastroduodenal ulcers in rats.

Peptides 11 , 293-297, (1990)

We have developed a novel series of peptides, related to the NKA(4-10) sequence, in which substitution of selected amino acids determined variations in the affinity for the TK receptor subtypes. Subcu...

Tachykinin-induced responses via neurokinin-1 and -3 receptors in hamster submandibular ganglion neurones.

Arch. Oral Biol. 44 , 455-463, (1999)

Both substance P and neurokinin A are known as neurotransmitters of the submandibular ganglion cell. In this study, the effects of neurokinin (NK) receptor-subtype agonists on hamster submandibular ga...

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