泛影葡胺

泛影葡胺用途

Diatrizoate meglumine is the meglumine salt form of diatrizoate, an organic, iodinated, radiopaque X-ray contrast medium used in diagnostic radiography.

泛影葡胺名称

[ CAS 号 ]:
131-49-7

[ 中文名 ]:
泛影葡胺

[ 英文名 ]:
Diatrizoate Meglumine

[英文别名 ]:

Megluminamidotrizoat
Diatrizoic Acid Methylglucamine
MFCD00069632
Meglumin-diazetrizoat
Diatrizoate methylglucamine
Diatrizoate Meglumine
Hypaque meglumine
Renograffin
Meglumine amidotrizoate
Renografin M-76

泛影葡胺物理化学性质

[ 密度 ]:
1.9465 (estimate)

[ 沸点 ]:
614.1ºC at 760mmHg

[ 熔点 ]:
189-193° (dec)

[ 分子式 ]:
C₁₈H₂₆I₃N₃O₉

[ 分子量 ]:
809.127

[ 精确质量 ]:
808.880310

[ PSA ]:
215.66000

[ LogP ]:
1.44700

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
6.19E-16mmHg at 25°C

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

泛影葡胺MSDS

详细MSDS(安全技术说明书)

泛影葡胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4315000

CHEMICAL NAME :: Glucitol, 1-deoxy-1-(methylamino)-, 3,5-diacetamido-2,4,6-triiodobenzoate (salt), D-

CAS REGISTRY NUMBER :: 131-49-7

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C11-H9-I3-N2-O4.C7-H17-N-O5

MOLECULAR WEIGHT :: 809.17

WISWESSER LINE NOTATION :: 1VMR BI DI FI CVQ EMV1 &Q1YQYQYQYQ1M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 214 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in both tubules and glomeruli Kidney, Ureter, Bladder - interstitial nephritis Kidney, Ureter, Bladder - urine volume decreased

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,392,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14565 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AAJRDX AJR, American Journal of Roentgenology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.126- 1976- Volume(issue)/page/year: 142,619,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 44504 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AAJRDX AJR, American Journal of Roentgenology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.126- 1976- Volume(issue)/page/year: 142,619,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 19500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 26,921,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,32,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,595,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81430 No. of Facilities: 86 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1252 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81430 No. of Facilities: 1221 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 27048 (estimated) No. of Female Employees: 17626 (estimated)

泛影葡胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
LZ4315000

泛影葡胺文献

In vitro immunomodulatory effects of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide on the cellular immune response.

Immunopharmacol. Immunotoxicol. 36(2) , 150-7, (2014)

The aim of this study was to determine the immunomodulatory activity of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide in vitro. This compound was used for the synthesis of a series of 5-amino-...

A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.

BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012)

The effect of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide on lymphocyte subsets and humoral immune response in SRBC-immunized mice.

Immunopharmacol. Immunotoxicol. 37(2) , 148-57, (2015)

5-Amino-3-methyl-4-isoxazolecarboxylic acid hydrazide is a non-cytotoxic synthetic isoxazole derivative with considerable immunomodulatory properties demonstrated in in vitro experiments. The aim of t...

更多文献