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盐酸乐卡地平

盐酸乐卡地平用途

Lercanidipine盐酸盐是二氢吡啶类钙离子通道阻断剂。

盐酸乐卡地平名称

[ CAS 号 ]:
132866-11-6

[ 中文名 ]:
盐酸乐卡地平

[ 英文名 ]:
Lercanidipine hydrochloride

[中文别名 ]:

[英文别名 ]:

Renovia
Vasodip
Carmen
Lercadip
Lercan
Lercaton
Lercapin
Lerdip
Cardiovasc
Lercanidipine hydrochloride

盐酸乐卡地平生物活性

[ 描述 ]:

Lercanidipine盐酸盐是二氢吡啶类钙离子通道阻断剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 心血管疾病

[参考文献]

[1]. Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70.

[2]. Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7.

[相关活性小分子]

盐酸乐卡地平物理化学性质

[ 沸点 ]:
712.5ºC at 760mmHg

[ 熔点 ]:
175-177ºC

[ 分子式 ]:
C₃₆H₄₂ClN₃O₆

[ 分子量 ]:
648.188

[ 闪点 ]:
384.7ºC

[ 精确质量 ]:
647.276184

[ PSA ]:
113.69000

[ LogP ]:
8.13240

[ 外观性状 ]:
灰白-黄色粉末

[ 蒸汽压 ]:
3.77E-20mmHg at 25°C

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
可溶于：甲醇

盐酸乐卡地平MSDS

详细MSDS(安全技术说明书)

盐酸乐卡地平安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S36/37-S45

[ 危险品运输编码 ]:
UN 2811

盐酸乐卡地平合成路线

详细合成路线

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盐酸乐卡地平文献

Differences in lercanidipine systemic exposure when administered according to labelling: in fasting state and 15 minutes before food intake.

Eur. J. Clin. Pharmacol. 68(7) , 1043-7, (2012)

The aim of this study was to compare the systemic exposure of lercanidipine (Zanidip) after oral administration in the fasted state and 15 min before food intake (meals) to investigate if the recommen...

Rationale for the use of a fixed-dose combination in the management of hypertension: efficacy and tolerability of lercanidipine/enalapril.

Clin. Drug Investig. 30(12) , 843-54, (2010)

Hypertension, a significant factor in the development of cerebrovascular disorders, heart disease and renal failure, is a common disorder worldwide. Despite the availability of a wide range of antihyp...

Lercanidipine rescues hippocampus pyramidal neurons from mild ischemia-induced delayed neuronal death in SHRSP.

Cell. Mol. Neurobiol. 31(4) , 561-7, (2011)

Stroke-prone spontaneously hypertensive rats (SHRSPs) are vulnerable to ischemia and delayed neuronal death (DND) of hippocampus pyramidal cells when bilateral carotid arteries are occluded for only 1...

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