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丙硫异烟胺

丙硫异烟胺用途

【用途一】
具有抑制结核菌，高浓度杀菌作用
【用途二】
具有抑制结核菌作用，高浓度杀菌。

丙硫异烟胺名称

[ CAS 号 ]:
14222-60-7

[ 中文名 ]:
丙硫异烟胺

[ 英文名 ]:
protionamide

[中文别名 ]:

2-丙基硫代异烟酰胺

[英文别名 ]:

2-propylpyridine-4-carbothioamide
EINECS 238-093-7
protionamide
2-Propyl-4-pyridinecarbothioamide
Propylthioisonicotinamide
4-Pyridinecarbothioamide, 2-propyl-
Prothionamide
MFCD00464119

丙硫异烟胺生物活性

[ 描述 ]:

Protionamide (prothionamide)可作用于结核病和麻风病。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Wang F, et al. Mechanism of thioamide drug action against tuberculosis and leprosy.J Exp Med. 2007 Jan 22;204(1):73-8.

[2]. Fajardo TT, et al. A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy. Am J Trop Med Hyg. 2006 Mar;74(3):457-61.

[相关活性小分子]

丙硫异烟胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
310.4±44.0 °C at 760 mmHg

[ 熔点 ]:
140ºC

[ 分子式 ]:
C₉H₁₂N₂S

[ 分子量 ]:
180.270

[ 闪点 ]:
141.5±28.4 °C

[ 精确质量 ]:
180.072113

[ PSA ]:
71.00000

[ LogP ]:
1.75

[ 外观性状 ]:
固体;Light yellow to Yellow to Orange powder to crystal

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.607

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
水溶性：不溶；易溶于：甲醇；可溶于：乙醇；极微溶：乙醚

丙硫异烟胺MSDS

丙硫异烟胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NS0650000

CHEMICAL NAME :: Isonicotinamide, 2-propylthio-

CAS REGISTRY NUMBER :: 14222-60-7

BEILSTEIN REFERENCE NO. :: 0118164

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H12-N2-S

MOLECULAR WEIGHT :: 180.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1320 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,471,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 760 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,726,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,471,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,726,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,471,1975

丙硫异烟胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933399090

丙硫异烟胺合成路线

丙硫异烟胺上下游产品

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丙硫异烟胺海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

丙硫异烟胺文献

A case of DRESS syndrome induced by the antituberculosis drugs, prothionamide, and para-aminosalycilic acid.

Ann. Allergy Asthma Immunol. 110(2) , 118-9, (2013)

Acceptability of thioamides. II. Prothionamide.

J. Postgrad. Med. 23(4) , 181-5, (1977)

Molecular structure and vibrational spectroscopic studies of prothionamide by density functional theory.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 152 , 262-71, (2016)

Prothionamide (PTH) is the secondary drug used against Mycobacterium tuberculosis bacteria and leprosy. The aim of this work was to investigate the potential energy surface map, anharmonic and harmoni...

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