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去甲氧基醉椒素

去甲氧基醉椒素用途

去甲氧基醉椒素(Desmethoxyyangonin)是MAO-B可逆性抑制剂。

去甲氧基醉椒素名称

[ CAS 号 ]:
15345-89-8

[ 中文名 ]:
去甲氧基醉椒素

[ 英文名 ]:
Desmethoxyyangonin

[中文别名 ]:

卡文内酯

[英文别名 ]:

DIHYDROKAVAIN
2H-Pyran-2-one, 4-methoxy-6-(2-phenylethenyl)-
2H-Pyran-2-one, 4-methoxy-6-[(E)-2-phenylethenyl]-
4-Methoxy-6-[(E)-2-phenylvinyl]-2H-pyran-2-one
4-methoxy-6-[(E)-2-phenylethenyl]-2H-pyran-2-one
Desmethoxyyangonin

去甲氧基醉椒素生物活性

[ 描述 ]:

去甲氧基醉椒素(Desmethoxyyangonin)是MAO-B可逆性抑制剂。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 单胺氧化酶

研究领域 >> 其他

天然产物 >> 其他

[参考文献]

[1]. Uebelhack R, et al. Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). Pharmacopsychiatry. 1998 Sep;31(5):187-92.

[2]. Baum SS, et al. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Oct;22(7):1105-20.

[3]. Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. Drug Metab Dispos. 2004 Nov;32(11):1317-24.

[相关活性小分子]

去甲氧基醉椒素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
440.0±45.0 °C at 760 mmHg

[ 熔点 ]:
138-140ºC

[ 分子式 ]:
C₁₄H₁₂O₃

[ 分子量 ]:
228.243

[ 闪点 ]:
188.0±23.3 °C

[ 精确质量 ]:
228.078644

[ PSA ]:
39.44000

[ LogP ]:
1.80

[ 外观性状 ]:
白色至淡的黄色粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.588

[ 储存条件 ]:
2-8°C

去甲氧基醉椒素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ1240000

CHEMICAL NAME :: 2H-Pyran-2-one, 4-methoxy-6-styryl-, (E)-

CAS REGISTRY NUMBER :: 15345-89-8

LAST UPDATED :: 199206

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H12-O3

MOLECULAR WEIGHT :: 228.26

WISWESSER LINE NOTATION :: T6OVJ DO1 F1U1R DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Behavioral - anticonvulsant

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969

去甲氧基醉椒素安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

去甲氧基醉椒素文献

Fatal kavalactone intoxication by suicidal intravenous injection.

Forensic Sci. Int. 249 , e7-11, (2015)

Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxioly...

Contribution to the quantitative and enantioselective determination of kavapyrones by high-performance liquid chromatography on ChiraSpher NT material.

J. Chromatogr. B. Biomed. Sci. Appl. 702(1-2) , 240-4, (1997)

A simultaneous HPLC separation of the enantiomers of kavain, dihydrokavain, methysticin and dihydromethysticin, as well as the achiral dienolides yangonin and desmethoxyyangonin was carried out on a C...

[Effects of the constituents of Alpinia speciosa rhizoma on experimental ulcers].

Taiwan Yi Xue Hui Za Zhi. 86(1) , 58-64, (1987)

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