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尔他培南钠

尔他培南钠用途

Ertapenem sodium 是一种新型的长效 1-β-甲基碳青霉烯类抗生素，具有很广的抗菌谱，包括常见的需氧菌和厌氧菌以及具有广谱 β-内酰胺酶的生物体。

尔他培南钠名称

[ CAS 号 ]:
153773-82-1

[ 中文名 ]:
厄他培南钠

[ 英文名 ]:
Ertapenem Sodium

[中文别名 ]:

[英文别名 ]:

2',4',6',3,4-PENTAHYDROXYDIHYDROCHALCONE
eriodictoyl dihydrochalcone
2',4',6',3,4-PENTAHYDROXYLDIHYDROCHALCONE
3-hydoxyphloretin
3'-hydroxyphloretin

尔他培南钠生物活性

[ 描述 ]:

Ertapenem sodium 是一种新型的长效 1-β-甲基碳青霉烯类抗生素,具有很广的抗菌谱,包括常见的需氧菌和厌氧菌以及具有广谱 β-内酰胺酶的生物体。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Hoellman DB, et al. In vitro antianaerobic activity of ertapenem (MK-0826) compared to seven other compounds. Antimicrob Agents Chemother. 2002 Jan;46(1):220-4.

[相关活性小分子]

尔他培南钠物理化学性质

[ 沸点 ]:
813.9ºC at 760 mmHg

[ 分子式 ]:
C₂₂H₂₄N₃NaO₇S

[ 分子量 ]:
497.49700

[ 闪点 ]:
446ºC

[ 精确质量 ]:
497.12300

[ PSA ]:
184.40000

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
5.26E-28mmHg at 25°C

[ 储存条件 ]:
-20℃

[ 水溶解性 ]:
Fully miscible in water. Soluble in DMSO.

尔他培南钠安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

尔他培南钠合成路线

详细合成路线

尔他培南钠文献

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis.

PLoS ONE 11 , e0148142, (2016)

Organ dysfunction is a major concern in sepsis pathophysiology and contributes to its high mortality rate. Neutrophil extracellular traps (NETs) have been implicated in endothelial damage and take par...

The Effect of Radiation Dose and Variation in Neupogen® Initiation Schedule on the Mitigation of Myelosuppression during the Concomitant GI-ARS and H-ARS in a Nonhuman Primate Model of High-dose Exposure with Marrow Sparing.

Health Phys. 109 , 427-39, (2015)

A nonhuman primate (NHP) model of acute high-dose, partial-body irradiation with 5% bone marrow (PBI/BM5) sparing was used to assess the effect of Neupogen® [granulocyte colony stimulating factor (G-C...

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