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NNGH

NNGH用途

NNGH是一种基质金属蛋白酶-1(MMP-3)抑制剂。MMP-3是Wnt/β-连环蛋白信号通路的直接转录靶点和必要贡献者。基质金属蛋白酶(MMP)在肿瘤进展的后期发挥着明确的作用[1]。

NNGH名称

[ CAS 号 ]:
161314-17-6

[ 英文名 ]:
NNGH

[英文别名 ]:

NNGH生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> MMP

[参考文献]

[1]. Laurence Blavier, et al. Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Ther. 2010 Jul 15;10(2):198-208.

NNGH物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 分子式 ]:
C₁₃H₂₀N₂O₅S

[ 分子量 ]:
316.373

[ 精确质量 ]:
316.109283

[ LogP ]:
1.94

[ 外观性状 ]:
固体

[ 折射率 ]:
1.547

[ 储存条件 ]:
2-8°C

NNGH安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

NNGH文献

Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stress.

PLoS ONE 9(12) , e115954, (2014)

In the present study we investigated the interplay between matrix metalloproteinase 3 (MMP3) and NADPH oxidase 1 (Nox1) in the process of dopamine (DA) neuronal death. We found that MMP3 activation ca...

Matrix Metalloproteinase-3 Promotes Early Blood–Spinal Cord Barrier Disruption and Hemorrhage and Impairs Long-Term Neurological Recovery after Spinal Cord Injury

Am. J. Pathol. 184(11) , 2985-3000, (2014)

After spinal cord injury (SCI), blood–spinal cord barrier (BSCB) disruption by matrix metalloproteinases (MMPs) leads to BSCB permeability and blood cell infiltration, contributing to permanent neurol...

Hox10-regulated endodermal cell migration is essential for development of the ascidian intestine.

Dev. Biol. 403 , 43-56, (2015)

Hox cluster genes play crucial roles in development of the metazoan antero-posterior axis. Functions of Hox genes in patterning the central nervous system and limb buds are well known. They are also e...

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