腺苷酸基琥珀酸

腺苷酸基琥珀酸用途

Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) 是一种嘌呤核糖核苷单磷酸,在核苷酸循环代谢 (nucleotide cycle metabolite) 中起作用。Adenylosuccinic acid 可以通过腺苷琥珀酸裂解酶转化成富马酸。Adenylosuccinic acid 有潜力用于杜氏肌营养不良症 (DMD) 的研究。

腺苷酸基琥珀酸名称

[ CAS 号 ]:
19046-78-7

[ 中文名 ]:
腺苷酸基琥珀酸

[ 英文名 ]:
Adenylosuccinic acid

[中文别名 ]:

腺苷酸基丁二酸

[英文别名 ]:

ADENYLOSUCCINIC ACID
N(6)-(1,2-dicarboxyethyl)-AMP
Aspartyl-AMP
adenylosuccnic acid
L-Aspartic acid 4-(5'-adenylyl) ester
Adenylobernsteinsaeure(L-)
Adenylsuccinic acid
aspartyl adenylate
N6-(1,2-dicarboxy-ethyl)-[5']adenylic acid
adenylosuccinic acid free acid

腺苷酸基琥珀酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

IC50: ribonucleoside monophosphate[1]

[体内研究]

腺苷酸(口服；3-3000微克/毫升；6周)显著改善了小鼠DMD的特征,降低了mdx胫前肌的中心纤维数、脂质积聚、结缔组织浸润和Ca2+含量[1]。动物模型：C57Bl/10ScSn(正常野生型；Con)和C57Bl/10mdx小鼠[1]剂量：3μg/mL、30μg/mL、300μg/mL、3000μg/mL给药：3μg/mL给药3天,30μg/mL给药4天,300μg/mL给药1周,结果：改善了小鼠duchenne型肌营养不良的症状。

[参考文献]

[1]. Timpani CA, et al. Adenylosuccinic acid therapy ameliorates murine Duchenne Muscular Dystrophy.Sci Rep. 2020 Jan 24;10(1):1125.

腺苷酸基琥珀酸物理化学性质

[ 密度 ]:
2.19g/cm3

[ 沸点 ]:
921.9ºC at 760mmHg

[ 分子式 ]:
C₁₄H₁₈N₅O₁₁P

[ 分子量 ]:
463.29300

[ 闪点 ]:
511.3ºC

[ 精确质量 ]:
463.07400

[ PSA ]:
256.49000

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.833

腺苷酸基琥珀酸MSDS

详细MSDS(安全技术说明书)

腺苷酸基琥珀酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

腺苷酸基琥珀酸合成路线

详细合成路线

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腺苷酸基琥珀酸文献

The RimL transacetylase provides resistance to translation inhibitor microcin C.

J. Bacteriol. 196(19) , 3377-85, (2014)

Peptide-nucleotide antibiotic microcin C (McC) is produced by some Escherichia coli strains. Inside a sensitive cell, McC is processed, releasing a nonhydrolyzable analog of aspartyl-adenylate, which ...

Synthesis and aminoacyl-tRNA synthetase inhibitory activity of aspartyl adenylate analogs.

Bioorg. Med. Chem. 13(1) , 69-75, (2005)

Three nonhydrolyzable aspartyl adenylate analogs have been prepared and tested as inhibitors of E. coli aspartyl-tRNA synthetase. 5'-O-[N-(L-Aspartyl)sulfamoyl]adenosine is a potent competitive inhibi...

MccE provides resistance to protein synthesis inhibitor microcin C by acetylating the processed form of the antibiotic.

J. Biol. Chem. 285(17) , 12662-9, (2010)

The heptapeptide-nucleotide microcin C (McC) is a potent inhibitor of enteric bacteria growth. McC is excreted from producing cells by the MccC transporter. The residual McC that remains in the produc...

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