左沙屈尔
左沙屈尔名称
[ CAS 号 ]:
23257-58-1
[ 中文名 ]:
左沙屈尔
[ 英文名 ]:
Piperidine,2-[(4R)-2,2-diphenyl-1,3-dioxolan-4-yl]-, hydrochloride (1:1), (2R)-
[中文别名 ]:
[英文别名 ]:
- Levoxadrol
- Levoxan
- Cl-912c
左沙屈尔物理化学性质
[ 沸点 ]:
468.4ºC at 760mmHg
[ 分子式 ]:
C20H24ClNO2
[ 分子量 ]:
345.86300
[ 闪点 ]:
237.1ºC
[ 精确质量 ]:
345.15000
[ PSA ]:
30.49000
[ LogP ]:
4.57600
[ 蒸汽压 ]:
3.6E-09mmHg at 25°C
左沙屈尔毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TM7640000
- CHEMICAL NAME :
- Piperidine, 2-(2,2-diphenyl-1,3-dioxolan-4-yl)-, hydrochloride, l-
- CAS REGISTRY NUMBER :
- 23257-58-1
- LAST UPDATED :
- 199012
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C20-H23-N-O2.Cl-H
- MOLECULAR WEIGHT :
- 345.90
- WISWESSER LINE NOTATION :
- T6MTJ B- DT5O COTJ BR& BR &GH -L
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 310 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,105,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 230 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,105,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Behavioral - anticonvulsant Behavioral - altered sleep time (including change in righting reflex)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,105,1965
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相关化合物
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