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9(S)-红霉素胺

9(S)-红霉素胺用途

Erythromycylamine 是一种大环内酯类抗生素。Erythromycylamine 对大多数革兰氏阳性球菌和结核分枝杆菌具有抗菌活性。

9(S)-红霉素胺名称

[ CAS 号 ]:
26116-56-3

[ 中文名 ]:
(9S)-9-氨基-9-脱氧乙琥红霉素

[ 英文名 ]:
9(S)-Erythromycylamine

[英文别名 ]:

MFCD00872156

9(S)-红霉素胺生物活性

[ 描述 ]:

Erythromycylamine 是一种大环内酯类抗生素。Erythromycylamine 对大多数革兰氏阳性球菌和结核分枝杆菌具有抗菌活性。

[ 相关类别 ]:

研究领域 >> 感染

[参考文献]

[1]. Naik S, et al. In vitro activities of several new macrolide antibiotics against Mycobacterium avium complex. Antimicrob Agents Chemother. 1989 Sep;33(9):1614-6.

[2]. Fernandes CJ, et al. Multi-centre collaborative study for the in vitro evaluation of new macrolides dirithromycin and erythromycylamine. Australian Group for Antimicrobial Resistance (AGAR). Pathology. 1995 Jan;27(1):74-8.

9(S)-红霉素胺物理化学性质

[ 密度 ]:
1.19g/cm3

[ 沸点 ]:
810.3ºC at 760mmHg

[ 分子式 ]:
C₃₇H₇₀N₂O₁₂

[ 分子量 ]:
734.96

[ 闪点 ]:
443.8ºC

[ 精确质量 ]:
734.49300

[ PSA ]:
202.86000

[ LogP ]:
2.24410

[ 蒸汽压 ]:
2.15E-30mmHg at 25°C

[ 折射率 ]:
1.539

[ 储存条件 ]:
2-8°C

9(S)-红霉素胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KF4590000

CHEMICAL NAME :: Erythromycin, 9-amino-9-deoxo-, stereoisomer

CAS REGISTRY NUMBER :: 26116-56-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C37-H70-N2-O12

MOLECULAR WEIGHT :: 735.09

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,83,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,83,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 57500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,83,1978

9(S)-红霉素胺安全信息

[ 危害码 (欧洲) ]:
Xi,N

[ 风险声明 (欧洲) ]:
41-50/53

[ 安全声明 (欧洲) ]:
26-39-60-61

9(S)-红霉素胺

9(S)-红霉素胺用途

9(S)-红霉素胺名称

9(S)-红霉素胺生物活性

9(S)-红霉素胺物理化学性质

9(S)-红霉素胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

9(S)-红霉素胺安全信息

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