Asoxime dichloride

Asoxime dichloride用途

Asoxime dichloride 是乙酰胆碱受体 (AChRs) 拮抗剂,包括烟碱受体,α7 乙酰胆碱受体。Asoxime dichloride 参与调节免疫应答。Asoxime dichloride 可作为抗原使用,改善神经系统的免疫效果。

Asoxime dichloride名称

[ CAS 号 ]:
34433-31-3

[ 中文名 ]:
HI-6

[ 英文名 ]:
Asoxime dichloride

[英文别名 ]:

Pralidoxime
hi-6dichloride
hj6
hi6
HI 6 Chloride

Asoxime dichloride生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 胆碱受体

信号通路 >> 神经信号通路 >> 胆碱受体

研究领域 >> 神经疾病

[ 靶点 ]

IC50: acetylcholine receptors (AChRs)[1]

[体内研究]

当KLH为1 mg/kg时,二氯阿索肟(肌肉注射到后肢；中致死剂量15.6和1.56 mg/kg的2%和0.2%；21或65天)以剂量依赖的方式显著提高疫苗接种效率。HI-6和keyhole-limpet-hemocyanin(KLH)的结合产生的免疫效果与弗氏完全佐剂的免疫效果几乎相同[1]。动物模型：Balb/c小鼠[1]剂量：中致死剂量15.6和1.56mg/kg的2%和0.2%；给药：后肢肌肉注射；结果：在神经系统免疫调节水平上提高了疫苗接种效果。

[参考文献]

[1]. Pohanka M, et al. HI-6 modulates immunization efficacy in a BALB/c mouse model.Environ Toxicol Pharmacol. 2013 Nov;36(3):801-6.

Asoxime dichloride物理化学性质

[ 熔点 ]:
145-147ºC

[ 分子式 ]:
C₁₄H₁₆Cl₂N₄O₃

[ 分子量 ]:
359.20800

[ 精确质量 ]:
358.06000

[ PSA ]:
92.67000

[ 外观性状 ]:
固体

[ 储存条件 ]:
20°C

Asoxime dichlorideMSDS

详细MSDS(安全技术说明书)

Asoxime dichloride毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU2990000

CHEMICAL NAME :: Pyridinium, 4'-carbamoyl-2-formyl-1,1'-(oxydimethylene)di-, dichloride, 2-oxime

CAS REGISTRY NUMBER :: 34433-31-3

LAST UPDATED :: 199703

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C14-H16-N4-O3.2Cl

MOLECULAR WEIGHT :: 359.24

WISWESSER LINE NOTATION :: T6KJ B1UNQ A1O1- AT6KJ DVZ &G 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 819 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 295 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 168 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 451 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 333 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 476 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg/14D-I

TOXIC EFFECTS :: Blood - changes in platelet count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1960 mg/kg/14D-I

TOXIC EFFECTS :: Cardiac - changes in heart weight Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 750 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 27,152,1996

Asoxime dichloride安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

Asoxime dichloride上下游产品

Asoxime dichloride上游产品

Asoxime dichloride下游产品

Asoxime dichloride文献

Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase.

Toxicol. Lett. 232(3) , 557-65, (2015)

Poisoning by organophosphorus compounds (OP) used as pesticides and nerve agents is due to irreversible inhibition of the enzyme acetylcholinesterase (AChE). Oximes have been widely recognized for the...

The effect of oxime reactivators on muscarinic receptors: functional and binding examinations.

Environ. Toxicol. Pharmacol. 31(3) , 364-70, (2011)

The antidotal treatment of organophosphorus poisoning is still a problematic issue since no versatile antidote has been developed yet. In our study, we focused on an interesting property, which does n...

Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.

Chem. Biol. Interact. 203(1) , 81-4, (2013)

Organophosphorus nerve agents (OPNAs) are highly toxic compounds that represent a threat to both military and civilian populations. They cause an irreversible inhibition of acetylcholinesterase (AChE)...

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