beta-雌二醇半水合物

beta-雌二醇半水合物用途

雌二醇(β-雌二醇)半水合物是一种类固醇激素,是主要的女性性激素。半水雌二醇(β-雌二醇)可上调人子宫内膜干细胞(hEnSCs)神经标记物的表达,促进其神经分化。雌二醇(β-雌二醇)半水合物可用于癌症、神经退行性疾病和神经组织工程的研究[1][2]。

beta-雌二醇半水合物名称

[ CAS 号 ]:
35380-71-3

[ 中文名 ]:
beta-雌二醇半水合物

[ 英文名 ]:
ESTRADIOL HEMIHYDRATE

[中文别名 ]:

[英文别名 ]:

ESTRADIOL HEMIHYDRATE
cxy7b3q98z
Estra-1,3,5(10)-triene-3,17β-diol hydrate (2:1)
unii-cxy7b3q98z

beta-雌二醇半水合物生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 癌症

研究领域 >> 神经疾病

[体外研究]

半水雌二醇(10 nM,7天)诱导人子宫内膜干细胞(HENSC)的神经分化和轴突分支增加[1]。半水雌二醇(17β-雌二醇,10 nM,7天)增加了从hEnSCs分化而来的神经样细胞中神经元样细胞标记物(Tuj-1、nestin和NF-H)的表达[1]。细胞分化试验[1]细胞系：从人子宫内膜组织中分离的人子宫内膜干细胞浓度：10 nM孵育时间：7天结果：神经标记物(Tuj-1、nestin和NF-H)阳性细胞百分比分别增加62.2±1.3%、71.5±4%和51.2±2.5%。免疫荧光[1]细胞系：从人子宫内膜组织中分离的人子宫内膜干细胞浓度：10 nM孵育时间：7天结果：神经标记物(Tuj-1、nestin和NF-H)阳性细胞百分比分别增加62.2±1.3%、71.5±4%和51.2±2.5%。

[体内研究]

半水合雌二醇(1 nM,来自FBN-ARO-KO小鼠的海马脑片)挽救长时程增强(LTP)幅度[1]。半水雌二醇(0.0167 mg,皮下注射,FBN-ARO-KO小鼠)可挽救FBN-ARO-KO鼠的分子和功能缺陷[1]。动物模型：FBN-ARO-KO小鼠[2]剂量：1nm给药：处理海马脑片结果：挽救雄性和雌性小鼠的长时程增强(LTP)幅度。动物模型：FBN-ARO-KO小鼠[2]剂量：0.0167 mg给药：Alzet微泵加雌二醇(皮下植入),在微泵植入7天后检查。结果：海马和皮层E2水平恢复到93%,海马和皮层AKT、ERK和CREB的磷酸化恢复到90-95%,BDNF水平恢复至80-90%,前脑突触素和PSD95均恢复。挽救了空间学习和记忆缺陷。

[参考文献]

[1]. Elham Hasanzadeh. Defining the role of 17β-estradiol in human endometrial stem cells differentiation into neuron-like cells. Cell Biol Int. 2021 Jan;45(1):140-153.

[2]. Yujiao Lu, et al. Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory. J Neurosci. 2019 Apr 10;39(15):2792-2809.

beta-雌二醇半水合物物理化学性质

[ 沸点 ]:
445.9ºC at 760mmHg

[ 分子式 ]:
C₁₈H₂₆O₃

[ 分子量 ]:
562.779

[ 闪点 ]:
209.6ºC

[ 精确质量 ]:
562.365845

[ PSA ]:
49.69000

[ LogP ]:
3.54490

[ 储存条件 ]:
2-8°C，密封，干燥

beta-雌二醇半水合物MSDS

详细MSDS(安全技术说明书)

beta-雌二醇半水合物安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H351-H360Fd-H362

[ 警示性声明 ]:
P201-P263-P281-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
60-63-40-64

[ 安全声明 (欧洲) ]:
53-36/37-45

[ 危险品运输编码 ]:
NONH for all modes of transport

beta-雌二醇半水合物文献

Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli.

Antimicrob. Agents Chemother. 51 , 923-9, (2007)

AcrAB-TolC is the major, constitutively expressed tripartite multidrug efflux system in Escherichia coli that recognizes various structurally unrelated molecules, including many antibiotics, dyes, and...

Development of a novel magnetic molecularly imprinted polymer coating using porous zeolite imidazolate framework-8 coated magnetic iron oxide as carrier for automated solid phase microextraction of estrogens in fish and pork samples.

J. Chromatogr. A. 1365 , 35-44, (2014)

A high-performance magnetic molecularly imprinted polymer (MIP) coating using zeolite imidazolate framework-8 coated magnetic iron oxide (Fe3O4@ZIF-8) as a carrier was developed for simultaneous autom...

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

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