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苄基-2-乙酰胺基-2-脱氧-Α-D-吡喃半乳糖苷

用途

O-glycosylation-IN-1 是一种有效的 O-糖基化 (O-glycosylation) 抑制剂,用于减少细胞表面的粘蛋白。O-glycosylation-IN-1 抑制人胰腺癌细胞模型黏蛋白 O-糖基化的合成。

名称

[ CAS 号 ]:
3554-93-6

[ 中文名 ]:
苄基-2-乙酰胺基-2-脱氧-Alpha-D-吡喃半乳糖苷

[ 英文名 ]:
O-glycosylation-IN-1

[中文别名 ]:

[英文别名 ]:

MFCD00057920
16beta-Hydroxydisitoxigenin

生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[ 靶点 ]

O-glycosylation[1]

[参考文献]

[1]. Kalra AV, et al. Mucin impedes cytotoxic effect of 5-FU against growth of human pancreatic cancer cells: overcoming cellular barriers for therapeutic gain. Br J Cancer. 2007 Oct 8;97(7):910-8. Epub 2007 Oct 2.

物理化学性质

[ 密度 ]:
1.34g/cm3

[ 沸点 ]:
594.9ºC at 760mmHg

[ 熔点 ]:
201-203°C

[ 分子式 ]:
C₁₅H₂₁NO₆

[ 分子量 ]:
311.33000

[ 闪点 ]:
313.6ºC

[ 精确质量 ]:
311.13700

[ PSA ]:
108.25000

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 折射率 ]:
1.59

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
methanol: soluble10mg/mL, clear

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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文献

Inhibition of CD44 N- and O-linked glycosylation decreases endometrial cell lines attachment to peritoneal mesothelial cells.

Fertil. Steril. 95(2) , 823-5, (2011)

The attachment of endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) with and without inhibition of N- and O-linked glycosylation, the viab...

Antiadhesive character of mucin O-glycans at the apical surface of corneal epithelial cells.

Invest. Ophthalmol. Vis. Sci. 49(1) , 197-203, (2008)

Prolonged contact of opposite mucosal surfaces, which occurs on the ocular surface, oral cavity, reproductive tract, and gut, requires a specialized apical cell surface that prevents adhesion. The pur...

Benzyl-N-acetyl-alpha-D-galactosaminide induces a storage disease-like phenotype by perturbing the endocytic pathway.

J. Biol. Chem. 278(14) , 12374-83, (2003)

The sugar analog O-benzyl-N-acetyl-alpha-d-galactosaminide (BG) is an inhibitor of glycan chain elongation and inhibits alpha2,3-sialylation in mucus-secreting HT-29 cells. Long-term exposure of these...

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