神经节苷酯GM₂

神经节苷脂GM2-asialo(asialo-GM2)是一种含三个单糖残基和一个可变链长脂肪酸的糖脂,但缺乏神经节苷脂M2上的唾液酸残基。Asialo-GM2在正常人脑中的水平较低或检测不到,但它在Tay-Sachs病和Sandhoff病患者的大脑中积累,这两种疾病表现为溶酶体β-一种以己糖胺酶A和B缺乏为特征的神经退行性疾病。它还与各种细菌结合,包括从囊性纤维化患者身上分离出来的假单胞菌。Asialo-GM2混合物含有神经节苷脂GM2 Asialo分子,具有可变长度的脂肪酰基链。

[ 描述 ]:

[ 相关类别 ]:

[ 分子式 ]:
C₅₆H₁₀₄N₂O₁₈

[ 分子量 ]:
1093.4

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

Asialo GM-2 developed on the fatty streak of atherosclerotic aorta detected by a novel monoclonal antibody (ASH1a/256C).

Ann. N. Y. Acad. Sci. 748 , 277-81; discussion 281-2, (1995)

Catabolism of asialo-GM2 in man and mouse. Specificity of human/mouse chimeric GM2 activator proteins.

J. Biol. Chem. 274(40) , 28612-8, (1999)

Tay-Sachs disease is an inborn lysosomal disease characterized by excessive cerebral accumulation of GM2. The catabolism of GM2 to GM3 in man requires beta-hexosaminidase A (HexA) and a protein cofact...

Optimal conditions to radiolabel (3H or 14C) aminosugar-containing glycosphingolipids by de-N-acetylation and re-N-acetylation.

Biochim. Biophys. Acta 1244(2-3) , 418-22, (1995)

The optimal conditions were examined for selective re-N-acetylation with 14C or 3H.acetic anhydride of de-N-acetylated aminosugar-containing glycosphingolipids. Re-N-acetylation, which is nearly quant...

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联系人：徐乾明

产品详情：神经节苷酯 GA2

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公司名：上海脉铂医药科技有限公司

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价格：
￥需询单/100mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：Ganglioside GM2 Asialo Mixture

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥1999.9/100mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁

产品详情：神经节苷酯 GA2

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