4025-59-6_5β,6β-epoxy CholestanolCAS号:4025-59-6_5β,6β-epoxy Cholestanol【结构式性质英文】

胆固醇5beta,6beta环氧化物是胆固醇的氧化代谢产物,由胆固醇在5,6双键上的自由基和非自由基氧化形成。[1] [2]在巨噬细胞分化的U937细胞中诱导乳酸脱氢酶(LDH)的释放和细胞凋亡。[3] 在人类脂肪条纹和晚期动脉粥样硬化病变中发现了5β,6β-环氧胆甾烷醇,但在正常主动脉组织中没有发现。[4] 参考文献：[1]。Pulfer,MK和Murphy,RC肺表面活性剂中胆固醇的臭氧分解过程中生物活性氧甾醇的形成。生物化学杂志279(25),26331-26338(2004)。[2]. Aringer,L.和Eneroth,P.胆固醇和β-谷甾醇5,6-环氧化物的体外形成和代谢。脂质研究杂志。15(4), 389-398 (1974).[3]. Lordan,S.、O'Brien,NM和Mackrill,JJ 7β-羟基胆固醇和胆固醇-5β,6β-环氧化物中的钙诱导的细胞凋亡。生物化学杂志。摩尔。毒药23(5), 324-332 (2009).[4]. Garcia Cruset,S.,Carpenter,KL,Guardiola,F.等人。正常人体动脉、脂肪条纹和晚期病变的氧化甾醇图谱。自由基。水库35(1), 31-41 (2001).

[ 描述 ]:

胆固醇5beta,6beta环氧化物是胆固醇的氧化代谢产物,由胆固醇在5,6双键上的自由基和非自由基氧化形成。[1] [2]在巨噬细胞分化的U937细胞中诱导乳酸脱氢酶(LDH)的释放和细胞凋亡。[3] 在人类脂肪条纹和晚期动脉粥样硬化病变中发现了5β,6β-环氧胆甾烷醇,但在正常主动脉组织中没有发现。[4] 参考文献：[1]。Pulfer,MK和Murphy,RC肺表面活性剂中胆固醇的臭氧分解过程中生物活性氧甾醇的形成。生物化学杂志279(25),26331-26338(2004)。[2]. Aringer,L.和Eneroth,P.胆固醇和β-谷甾醇5,6-环氧化物的体外形成和代谢。脂质研究杂志。15(4), 389-398 (1974).[3]. Lordan,S.、O'Brien,NM和Mackrill,JJ 7β-羟基胆固醇和胆固醇-5β,6β-环氧化物中的钙诱导的细胞凋亡。生物化学杂志。摩尔。毒药23(5), 324-332 (2009).[4]. Garcia Cruset,S.,Carpenter,KL,Guardiola,F.等人。正常人体动脉、脂肪条纹和晚期病变的氧化甾醇图谱。自由基。水库35(1), 31-41 (2001).

[ 相关类别 ]:

研究领域 >> 其他

[ 密度 ]:
1.04g/cm3

[ 沸点 ]:
497.7ºC at 760 mmHg

[ 分子式 ]:
C₂₇H₄₆O₂

[ 分子量 ]:
402.65300

[ 闪点 ]:
200.9ºC

[ 精确质量 ]:
402.35000

[ PSA ]:
32.76000

[ LogP ]:
6.59990

[ 蒸汽压 ]:
5.43E-12mmHg at 25°C

[ 折射率 ]:
1.533

[ 储存条件 ]:
-20°C，密封，干燥

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ6380000

CHEMICAL NAME :: 5-beta-Cholestan-3-beta-ol, 5,6-beta-epoxy-

CAS REGISTRY NUMBER :: 4025-59-6

LAST UPDATED :: 199410

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C27-H46-O2

MOLECULAR WEIGHT :: 402.73

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,355,1988

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22-48/20/21/22

[ 安全声明 (欧洲) ]:
7-36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

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J. Biol. Chem. 279(25) , 26331-8, (2004)

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Cell Biol. Toxicol. 17(2) , 127-37, (2001)

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区域：上海市嘉定区

价格：
￥3556.0/100mg ￥607.0/10mg ￥2131.0/50mg ￥需询单/1g

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