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PSB 36

PSB 36用途

PSB36是一种有效的选择性腺苷A1受体拮抗剂,rA1、hA2B、rA2A、hA3和rA3受体的Kis分别为0.12nm、187nm、552nm、2300nm和6500nm。PSB36可用于痛觉过敏的研究[1][2]。

PSB 36名称

[ CAS 号 ]:
524944-72-7

[ 英文名 ]:
PSB 36

[英文别名 ]:

hms3268h03

PSB 36生物活性

[ 描述 ]:

PSB36是一种有效的选择性腺苷A1受体拮抗剂,rA1、hA2B、rA2A、hA3和rA3受体的Kis分别为0.12nm、187nm、552nm、2300nm和6500nm。PSB36可用于痛觉过敏的研究[1][2]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

[ 靶点 ]

rA1:0.12 nM (Ki)

hA2B:187 nM (Ki)

rA2A:552 nM (Ki)

hA3:2300 nM (Ki)

rA3:6500 nM (Ki)

[参考文献]

[1]. Abo-Salem OM, et, al. Antinociceptive effects of novel A2B adenosine receptor antagonists. J Pharmacol Exp Ther. 2004 Jan;308(1):358-66.

[2]. Bilkei-Gorzo A, et, al. Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia. Naunyn Schmiedebergs Arch Pharmacol. 2008 Mar;377(1):65-76.

PSB 36物理化学性质

[ 密度 ]:
1.304g/cm3

[ 沸点 ]:
646.008ºC at 760 mmHg

[ 分子式 ]:
C₂₁H₃₀N₄O₃

[ 分子量 ]:
386.48800

[ 闪点 ]:
344.493ºC

[ 精确质量 ]:
386.23200

[ PSA ]:
92.91000

[ LogP ]:
2.14650

[ 折射率 ]:
1.616

PSB 36MSDS

详细MSDS(安全技术说明书)

PSB 36安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

PSB 36文献

The protective effects of CD39 overexpression in multiple low-dose streptozotocin-induced diabetes in mice.

Diabetes 62(6) , 2026-35, (2013)

Islet allograft survival limits the long-term success of islet transplantation as a potential curative therapy for type 1 diabetes. A number of factors compromise islet survival, including recurrent d...

Diadenosine diphosphate (Ap₂A) delays neutrophil apoptosis via the adenosine A2A receptor and cAMP/PKA pathway.

Biochem. Cell Biol. 92(5) , 420-4, (2014)

Diadenosine polyphosphates have been shown to inhibit neutrophil apoptosis, but mechanisms of the antiapoptotic effect are not known. Diadenosine diphosphate (Ap2A) is the simplest naturally occurring...

Antinociceptive effects of novel A2B adenosine receptor antagonists.

J. Pharmacol. Exp. Ther. 308 , 358-366, (2004)

Caffeine, an adenosine A1, A2A, and A2B receptor antagonist, is frequently used as an adjuvant analgesic in combination with nonsteroidal anti-inflammatory drugs or opioids. In this study, we have exa...

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