盐酸丙嗪
盐酸丙嗪用途
盐酸丙嗪名称
[ CAS 号 ]:
53-60-1
[ 中文名 ]:
普马嗪 盐酸盐
[ 英文名 ]:
Promazine hydrochloride
[中文别名 ]:
[英文别名 ]:
- MFCD00058535
- Promazine Hydrochloride
- EINECS 200-179-7
盐酸丙嗪生物活性
盐酸丙嗪物理化学性质
[ 沸点 ]:
412.7ºC at 760mmHg
[ 熔点 ]:
174-176ºC
[ 分子式 ]:
C17H21ClN2S
[ 分子量 ]:
320.88000
[ 闪点 ]:
203.4ºC
[ 精确质量 ]:
320.11100
[ PSA ]:
31.78000
[ LogP ]:
5.10800
[ 外观性状 ]:
粉末
[ 储存条件 ]:
2-8°C
盐酸丙嗪MSDS
盐酸丙嗪毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SO8575000
- CHEMICAL NAME :
- Phenothiazine, 10-(3-(dimethylamino)propyl)-, monohydrochloride
- CAS REGISTRY NUMBER :
- 53-60-1
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C17-H20-N2-S.Cl-H
- MOLECULAR WEIGHT :
- 320.91
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B3N1&1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 20 mg/kg/D-I
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - tremor Behavioral - antipsychotic
- REFERENCE :
- JNMDAN Journal of Nervous and Mental Disease. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.3- 1876- Volume(issue)/page/year: 123,553,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 5,269,1963
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 356 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 54,295,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 29 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,42,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,42,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 38 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,42,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APMCB4 Annales Pharmaceutic. (Poznan, Poland) V.3-13, 1965-78. Discontinued. Volume(issue)/page/year: 13,51,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 4400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,-,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,42,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3224 No. of Facilities: 57 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1876 (estimated) No. of Female Employees: 940 (estimated)
盐酸丙嗪安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302-H317
[ 警示性声明 ]:
P280
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn: Harmful;
[ 风险声明 (欧洲) ]:
R22;R43
[ 安全声明 (欧洲) ]:
S36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
SO8575000
[ 海关编码 ]:
2934300000
盐酸丙嗪合成路线
盐酸丙嗪上下游产品
盐酸丙嗪上游产品
盐酸丙嗪下游产品
盐酸丙嗪海关
[ 海关编码 ]: 2934300000
[ 中文概述 ]:
2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
盐酸丙嗪文献
Chem. Res. Toxicol. 23 , 1215-22, (2010)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...
A predictive ligand-based Bayesian model for human drug-induced liver injury.Drug Metab. Dispos. 38 , 2302-8, (2010)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...
Chemical genetics reveals a complex functional ground state of neural stem cells.Nat. Chem. Biol. 3(5) , 268-273, (2007)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...
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相关药品:
推荐生产厂家/供应商:
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥392.0/5mg
联系人:夏言
产品详情:[Perfemiker]Promazine hydrochloride,GR
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥59.9/50mg
¥299.9/1g
¥159.9/250mg
¥799.9/5g
联系人:阿拉丁
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相关化合物
【盐酸丙嗪】化源网提供盐酸丙嗪CAS号53-60-1,盐酸丙嗪MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询盐酸丙嗪上化源网,专业又轻松。>>电脑版:盐酸丙嗪
标题:盐酸丙嗪_MSDS_用途_熔点_盐酸丙嗪CAS号【53-60-1】_化源网 地址:https://www.chemsrc.com/amp/cas/53-60-1_830774.html