四氧普林

四氧普林用途

四氢呋喃是一种抗菌DHFR抑制剂[1]。

四氧普林名称

[ CAS 号 ]:
53808-87-0

[ 中文名 ]:
四氧普林

[ 英文名 ]:
Tetroxoprim

[中文别名 ]:

[英文别名 ]:

四氧普林生物活性

[ 描述 ]:

四氢呋喃是一种抗菌DHFR抑制剂[1]。

[ 相关类别 ]:

研究领域 >> 感染
信号通路 >> 细胞周期/DNA损伤 >> 叶酸
研究领域 >> 炎症/免疫

[体外研究]

在浓度为4 x 10-9M的大肠杆菌中,四氢呋喃可产生50%的体外抑制作用[1]。

[参考文献]

[1]. H S Aschhoff, et al. Tetroxoprim--a new inhibitor of bacterial dihydrofolate reductase. J Antimicrob Chemother. 1979 Nov;5(B):19-25.

四氧普林物理化学性质

[ 密度 ]:
1.232g/cm3

[ 沸点 ]:
564.1ºC at 760mmHg

[ 分子式 ]:
C16H22N4O4

[ 分子量 ]:
334.37

[ 闪点 ]:
294.9ºC

[ 精确质量 ]:
334.16400

[ PSA ]:
114.74000

[ LogP ]:
2.43660

[ 折射率 ]:
1.587

[ 储存条件 ]:
2-8°C，避光，干燥，密封

四氧普林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV8190000
CHEMICAL NAME :
Pyrimidine, 2,4-diamino-5-(3,5-dimethoxy-4-(2-methoxyethoxy)benzy l)-
CAS REGISTRY NUMBER :
53808-87-0
BEILSTEIN REFERENCE NO. :
4271695
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C16-H22-N4-O4
MOLECULAR WEIGHT :
334.42
WISWESSER LINE NOTATION :
T6N CNJ BZ DZ E1R CO1 EO1 DO2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1172 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,895,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,895,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1060 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
192 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,895,1979

四氧普林安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2933599090

四氧普林海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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相关化合物

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