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5-羟色胺酸

5-羟色胺酸用途

5-Hydroxytryptophan 是色氨酸的代谢物,是一种直接的5-羟色胺 (5-HT) 前体,是芳香氨基酸脱羧酶底物。

5-羟色胺酸名称

[ CAS 号 ]:
56-69-9

[ 中文名 ]:
5-羟基色氨酸

[ 英文名 ]:
5-Hydroxytryptophan

[中文别名 ]:

[英文别名 ]:

MFCD00005651
5-HYDROXY-TRYPTOPHAN
Tryptophan, 5-hydroxy-, DL-
5-Hydroxytryptophan DL-form
DL-5-HTP
Tryptophan, 5-hydroxy-
EINECS 200-284-8
(±)-5-hydroxytryptophan
5-Hydroxytryptophan
5-Hydroxy Tryptophan

5-羟色胺酸生物活性

[ 描述 ]:

5-Hydroxytryptophan 是色氨酸的代谢物,是一种直接的5-羟色胺 (5-HT) 前体,是芳香氨基酸脱羧酶底物。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Gartside SE, et al. Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors. Eur J Pharmacol. 1990 Apr 10;179(1-2):103-9.

[2]. Gijsman HJ, et al. Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers. J Clin Psychopharmacol. 2002 Apr;22(2):183-9.

[3]. Schruers K, et al. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. Psychiatry Res. 2002 Dec 30;113(3):237-43.

5-羟色胺酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
520.6±50.0 °C at 760 mmHg

[ 熔点 ]:
298-300ºC

[ 分子式 ]:
C₁₁H₁₂N₂O₃

[ 分子量 ]:
220.225

[ 闪点 ]:
268.7±30.1 °C

[ 精确质量 ]:
220.084793

[ PSA ]:
99.34000

[ LogP ]:
-0.14

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.737

[ 储存条件 ]:
2-8°C

5-羟色胺酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YN7000000

CHEMICAL NAME :: Tryptophan, 5-hydroxy-

CAS REGISTRY NUMBER :: 56-69-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H12-N2-O3

MOLECULAR WEIGHT :: 220.25

WISWESSER LINE NOTATION :: T56 BMJ D1YZVQ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 30 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

REFERENCE :: ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd. Saint-Germain, F-25280 Paris Cedex 06, France) V.1- 1939- Volume(issue)/page/year: 24(Suppl 3),1,1963 *** REVIEWS *** TOXICOLOGY REVIEW CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964

5-羟色胺酸安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36/37/38-65-20/21/22-20/21

[ 安全声明 (欧洲) ]:
24/25-22

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3.0

[ RTECS号 ]:
YN7100000

[ 包装等级 ]:
III

[ 海关编码 ]:
2929909090

5-羟色胺酸合成路线

详细合成路线

5-羟色胺酸上下游产品

5-羟色胺酸上游产品

5-羟色胺酸下游产品

5-羟色胺酸海关

[ 海关编码 ]: 2929909090

[ 中文概述 ]:
2929909090 其他含氮基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%