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卡前列素氨基丁三醇

卡前列素氨基丁三醇用途

Carboprost tromethamine 是前列腺素 F2α (prostaglandin F2α) 的 15 甲基类似物。Carboprost tromethamine 能有效促进子宫规律性收缩,显著减少产后出血量。

卡前列素氨基丁三醇名称

[ CAS 号 ]:
58551-69-2

[ 中文名 ]:
卡前列素氨基丁三醇

[ 英文名 ]:
Carboprost tromethamine

[中文别名 ]:

卡前列腺氨丁三醇

[英文别名 ]:

(15S)-15-Methylprostaglandin F2a Tromethamine
Hemabate
Prostin/15M
Carboprost tromethamine salt
15(S)15-Methyl pgf2a Tromethamine Salt
Carboprost trometamol
Carboprost tromethamine
U 32921E

卡前列素氨基丁三醇生物活性

[ 描述 ]:

Carboprost tromethamine 是前列腺素 F2α (prostaglandin F2α) 的 15 甲基类似物。Carboprost tromethamine 能有效促进子宫规律性收缩,显著减少产后出血量。

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

[体内研究]

卡前列素氨丁三醇对预防剖宫产产后出血有显著作用,对改善高凝状态、维持血流动力学稳定有显著作用。卡前列素氨丁三醇治疗因子宫收缩乏力而持续出血的成功率为84-96%。

[参考文献]

[1]. Ling Z, et al. Effect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section. Pak J Pharm Sci. 2018 Sep;31(5(Special)):2257-2262.

[2]. Bai J, et al. A comparison of oxytocin and carboprost tromethamine in the prevention of postpartum hemorrhage in high-risk patients undergoing cesarean delivery. Exp Ther Med. 2014 Jan;7(1):46-50. Epub 2013 Nov 1.

卡前列素氨基丁三醇物理化学性质

[ 密度 ]:
1.153g/cm3

[ 沸点 ]:
536.6ºC at 760 mmHg

[ 分子式 ]:
C₂₅H₄₇NO₈

[ 分子量 ]:
489.643

[ 闪点 ]:
292.4ºC

[ 精确质量 ]:
489.330170

[ PSA ]:
184.70000

[ LogP ]:
1.79410

[ 储存条件 ]:
2-8°C，密闭，干燥

[ 水溶解性 ]:
Soluble in water.

卡前列素氨基丁三醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UK8026000

CAS REGISTRY NUMBER :: 58551-69-2

LAST UPDATED :: 198910

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C21-H36-O5.C4-H11-N-O3

MOLECULAR WEIGHT :: 489.73

WISWESSER LINE NOTATION :: L5TJ AQ B2U4VQ C1U1XQ5&1 DQ &Q1XZ1Q1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 131 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 30 ug/kg

SEX/DURATION :: female 14 week(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 11,533,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 87 ug/kg

SEX/DURATION :: female 15-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :: APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 87 ug/kg

SEX/DURATION :: female 15-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition Reproductive - Fertility - abortion Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 6 mg/kg

SEX/DURATION :: male 3 day(s) pre-mating female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 300 ug/kg

SEX/DURATION :: female 9-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978

卡前列素氨基丁三醇安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

卡前列素氨基丁三醇文献

[The use of prostaglandin F2alpha (Prostin 15M) for terminationof second trimester pregnancy].

Akush. Ginekol. (Sofiia.) 52(2) , 53-5, (2013)

The authors describe a case of terminating a second trimester pregnancy in 21 gestational weeks with use of Prostin 15 M. The patient come to the clinic in 21 gestational week with spontaneous rupture...

[Application of Pfizer drugs in the obstetrics and gynecology practice].

Akush. Ginekol. (Sofiia.) 48 Suppl 1 , 41-4, (2009)

[Some possibilities for application of Pfizer medicines--Prostin 15m, Prostin E2, Prepidil gel, Dostinex, Synarel--in the obstetrician practice].

Akush. Ginekol. (Sofiia.) 46 Suppl 2 , 57-60, (2007)

The authors make a clinical and pharmacological overview of the possibilities of application in the obstetrician practice of part of the medicines of the company Pfiser. Some of these medicines have n...

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