TRIPELENNAMINE CITRATE

TRIPELENNAMINE CITRATE用途

柠檬酸三苯那敏是一种乙二胺衍生物,是一种有效的组胺H1受体拮抗剂。柠檬酸三苯那敏可以减轻由组胺引起的机体过敏反应。柠檬酸三苯那敏可用于研究鼻炎、结膜炎、过敏和过敏反应[1][2][3]。

TRIPELENNAMINE CITRATE名称

[ CAS 号 ]:
6138-56-3

[ 英文名 ]:
TRIPELENNAMINE CITRATE

[英文别名 ]:

Pyribenzamine citrate
EINECS 228-121-6
Tripelennamine citrate

TRIPELENNAMINE CITRATE生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 内分泌

研究领域 >> 炎症/免疫

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

[ 靶点 ]

H1 Receptor

[参考文献]

[1]. Manohar M, et al. H1-receptor antagonist, tripelennamine, does not affect arterial hypoxemia in exercising Thoroughbreds. J Appl Physiol. 2002 Apr;92(4):1515-23.

[2]. Wasfi IA, et al. Comparative disposition of tripelennamine in horses and camels after intravenous administration. J Vet Pharmacol Ther. 2000 Jun;23(3):145-52.

[3]. Yeh SY, et al. The pharmacokinetics of pentazocine and tripelennamine. Clin Pharmacol Ther. 1986 Jun;39(6):669-76.

TRIPELENNAMINE CITRATE物理化学性质

[ 沸点 ]:
387.8ºC at 760 mmHg

[ 熔点 ]:
106-110°

[ 分子式 ]:
C₂₂H₂₉N₃O₇

[ 分子量 ]:
447.48200

[ 闪点 ]:
188.3ºC

[ 精确质量 ]:
447.20100

[ PSA ]:
151.50000

[ LogP ]:
1.40130

TRIPELENNAMINE CITRATE毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US2950000

CAS REGISTRY NUMBER :: 6138-56-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H21-N3.C6-H8-O7

MOLECULAR WEIGHT :: 447.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 6168 ug/kg/12H

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions

REFERENCE :: CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 16,331,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80566 No. of Facilities: 460 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 3946 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80566 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1957 (estimated) No. of Female Employees: 1888 (estimated)

TRIPELENNAMINE CITRATE安全信息

[ 危险品运输编码 ]:
UN 3249

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)