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乙胺香豆素盐酸盐

乙胺香豆素盐酸盐用途

Chromonar hydrochloride is a coronary vasodilator agent. It increases in transmural blood flow.

乙胺香豆素盐酸盐名称

[ CAS 号 ]:
655-35-6

[ 中文名 ]:
乙胺香豆素盐酸盐

[ 英文名 ]:
Chromonar hydrochloride

[英文别名 ]:

Carboc
Carbochromen-hydrochlorid
intercordin
carbocromene
CarbochroMen Hydrochloride
intensain hydrochloride
antiangor
CARBOCROMENE HYDROCHLORIDE
carbocromen hydrochloride
carbochromene hydrochloride

乙胺香豆素盐酸盐物理化学性质

[ 沸点 ]:
488.6ºC at 760 mmHg

[ 熔点 ]:
159-160ºC

[ 分子式 ]:
C₂₀H₂₈ClNO₅

[ 分子量 ]:
397.89300

[ 闪点 ]:
249.3ºC

[ 精确质量 ]:
397.16600

[ PSA ]:
68.98000

[ LogP ]:
3.72960

[ 储存条件 ]:
库房低温通风干燥

乙胺香豆素盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG9500000

CHEMICAL NAME :: Acetic acid, ((3-(2-(diethylamino)ethyl)-4-methyl-2-oxo)-2H-1-benz opyran-7-yl)oxy-, ethyl ester, hydrochloride

CAS REGISTRY NUMBER :: 655-35-6

LAST UPDATED :: 199706

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C20-H27-N-O5.Cl-H

MOLECULAR WEIGHT :: 397.94

WISWESSER LINE NOTATION :: L66 BOVT&J D2N2&2 E1 IO1VO2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 27(4),48,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,243,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 528 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,243,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 9,57,1975

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 173 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,243,1963 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/m3/17W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 27(4),48,1983 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.3 mg/m3 JAN 1993