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氨基葡萄糖盐酸盐

氨基葡萄糖盐酸盐用途

盐酸氨基葡萄糖 (Glucosamine hydrochloride) 是一种天然产物。

氨基葡萄糖盐酸盐名称

[ CAS 号 ]:
66-84-2

[ 中文名 ]:
D-氨基葡萄糖盐酸盐

[ 英文名 ]:
D-Glucosamine hydrochloride

[中文别名 ]:

[英文别名 ]:

EINECS 200-638-1
MFCD00135831
Glucopyranose, 2-amino-2-deoxy-, hydrochloride, D-
Glucosamine (hydrochloride)

氨基葡萄糖盐酸盐生物活性

[ 描述 ]:

盐酸氨基葡萄糖 (Glucosamine hydrochloride) 是一种天然产物。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 代谢酶/蛋白酶 >> HIF/HIF脯氨酰-羟化酶

研究领域 >> 其他

天然产物 >> 糖和糖苷

[参考文献]

[1]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9.

[2]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706.

[3]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84.

[相关活性小分子]

氨基葡萄糖盐酸盐物理化学性质

[ 沸点 ]:
449.9ºC at 760 mmHg

[ 熔点 ]:
190-194ºC

[ 分子式 ]:
C₆H₁₄ClNO₅

[ 分子量 ]:
215.632

[ 闪点 ]:
225.9ºC

[ 精确质量 ]:
215.056046

[ PSA ]:
124.01000

[ 外观性状 ]:
白色粉末晶体

[ 折射率 ]:
72 ° (C=1， H2O)

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

氨基葡萄糖盐酸盐MSDS

氨基葡萄糖盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ6665000

CHEMICAL NAME :: D-Glucose, 2-amino-2-deoxy-, hydrochloride

CAS REGISTRY NUMBER :: 66-84-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C6-H13-N-O5.Cl-H

MOLECULAR WEIGHT :: 215.66

WISWESSER LINE NOTATION :: VHYZYQYQYQ1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - sensory change involving peripheral nerve

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6200 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - sensory change involving peripheral nerve

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - sensory change involving peripheral nerve

MUTATION DATA

TEST SYSTEM :: Fish - not otherwise specified

DOSE/DURATION :: 1000 ppm

REFERENCE :: NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- Volume(issue)/page/year: 28,176,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T2043 No. of Facilities: 1651 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 16143 (estimated) No. of Female Employees: 13164 (estimated)

氨基葡萄糖盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F: Flammable;Xi: Irritant;Xn: Harmful;

[ 风险声明 (欧洲) ]:
R21

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
LZ6665000

[ 海关编码 ]:
2932999099

氨基葡萄糖盐酸盐合成路线

氨基葡萄糖盐酸盐上下游产品

氨基葡萄糖盐酸盐上游产品

氨基葡萄糖盐酸盐下游产品

氨基葡萄糖盐酸盐海关

[ 海关编码 ]: 2922399090

[ 中文概述 ]:
2922399090 其他氨基醛、氨基酮及其盐（包括氨基醌及其盐，但含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

氨基葡萄糖盐酸盐文献

The hexosamine biosynthesis pathway and O-GlcNAcylation maintain insulin-stimulated PI3K-PKB phosphorylation and tumour cell growth after short-term glucose deprivation.

FEBS J. 281(16) , 3591-608, (2014)

Glucose provides an essential nutrient source that supports glycolysis and the hexosamine biosynthesis pathway (HBP) to maintain tumour cell growth and survival. Here we investigated if short-term glu...

Qualitative and quantitative determination of peptides related to celiac disease in mixtures derived from different methods of simulated gastrointestinal digestion of wheat products.

Anal. Bioanal. Chem 406(19) , 4765-75, (2014)

During wheat digestion, gluten-derived proteolytic resistant peptides are generated, some of them involved in celiac disease. In vitro digestion models able to mimic the peptides generated in the huma...

The dissolution enhancement of piroxicam in its physical mixtures and solid dispersion formulations using gluconolactone and glucosamine hydrochloride as potential carriers.

Pharm. Dev. Technol. 20(1) , 74-83, (2015)

The solid dispersion technique is one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs; however this is reliant on a suitable carrier and solvent being se...

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