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美芬妥英

美芬妥英用途

(S) -美苯妥英(+)-美苯妥英)是一种抗惊厥剂。(S) -美苯妥英是细胞色素P450(CYP)亚型CYP2C19的底物。(S) -美苯妥英可用于分析细胞色素P450代谢[1][2]。

美芬妥英名称

[ CAS 号 ]:
70989-04-7

[ 中文名 ]:
甲秦皮素

[ 英文名 ]:
(S)-Mephenytoin

[中文别名 ]:

[英文别名 ]:

S(+)-5-Ethyl-3-methyl-5-phenylhydantoin
S(+)-5-Ethyl-1-methyl-5-phenylbarbituric acid
S-mephenytoin
(+)-Mephobarbitol
5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione
5-éthyl-3-méthyl-5-phénylimidazolidine-2,4-dione
5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione
(S)-Mephenytoin
mephenytoin
[14C]-(+)-Mephenytoin

美芬妥英生物活性

[ 描述 ]:

(S) -美苯妥英(+)-美苯妥英)是一种抗惊厥剂。(S) -美苯妥英是细胞色素P450(CYP)亚型CYP2C19的底物。(S) -美苯妥英可用于分析细胞色素P450代谢[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

在存在细胞色素b5的情况下,所有五种纯化的细胞色素P-450s制剂的S-美苯妥英的Km为1.25 mM[1]。

[参考文献]

[1]. Shimada T, et, al. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. J Biol Chem. 1986 Jan 15;261(2):909-21.

[2]. Goldstein JA, et, al. Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans. Biochemistry. 1994 Feb 22;33(7):1743-52.

美芬妥英物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 熔点 ]:
135-138ºC

[ 分子式 ]:
C₁₂H₁₄N₂O₂

[ 分子量 ]:
218.252

[ 精确质量 ]:
218.105530

[ PSA ]:
49.41000

[ LogP ]:
1.40

[ 外观性状 ]:
白色固体

[ 折射率 ]:
1.541

[ 储存条件 ]:
2-8°C

美芬妥英MSDS

详细MSDS(安全技术说明书)

美芬妥英安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

美芬妥英上下游产品

美芬妥英上游产品

美芬妥英下游产品

美芬妥英文献

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine.

Malaria Journal 11 , 259, (2012)

The 8-aminoquinoline (8AQ) drug primaquine (PQ) is currently the only approved drug effective against the persistent liver stage of the hypnozoite forming strains Plasmodium vivax and Plasmodium ovale...

Trade herbal products and induction of CYP2C19 and CYP2E1 in cultured human hepatocytes.

Basic Clin Pharmacol Toxicol. 105(1) , 58-63, (2009)

The aim of this study was to evaluate in vitro the dose-dependent induction potential of six commonly used trade herbal products on CYP2C19 and CYP2E1 metabolic activities in cultured human hepatocyte...

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