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6-十二酰基-N,N-二甲基-2-萘胺(Laurdan)

6-十二酰基-N,N-二甲基-2-萘胺(Laurdan)用途

劳丹是一种膜渗透性荧光探针,它对与之结合的细胞膜的磷脂相显示光谱敏感性。劳丹的广义极化(GP)定量可用于磷脂相的鉴别。

6-十二酰基-N,N-二甲基-2-萘胺(Laurdan)名称

[ CAS 号 ]:
74515-25-6

[ 中文名 ]:
6-十二酰基-N,N-二甲基-2-萘胺

[ 英文名 ]:
Laurdan

[英文别名 ]:

6-Dodecanoyl-N,N-dimethyl-2-naphthylamine
N,N-Dimethyl-6-dodecanoyl-2-naphthylamine
Laurdan
2-(Dimethylamino)-6-dodecanoylnaphthalene
6-Dodecanoyl-2-dimethylaminonaphthalene

6-十二酰基-N,N-二甲基-2-萘胺(Laurdan)生物活性

[ 描述 ]:

劳丹是一种膜渗透性荧光探针,它对与之结合的细胞膜的磷脂相显示光谱敏感性。劳丹的广义极化(GP)定量可用于磷脂相的鉴别。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

6-十二酰基-N,N-二甲基-2-萘胺(Laurdan)物理化学性质

[ 密度 ]:
0.987g/cm3

[ 沸点 ]:
497.4ºC at 760 mmHg

[ 熔点 ]:
88ºC(lit.)

[ 分子式 ]:
C₂₄H₃₅NO

[ 分子量 ]:
353.54100

[ 闪点 ]:
177.4ºC

[ 精确质量 ]:
353.27200

[ PSA ]:
20.31000

[ LogP ]:
7.00940

[ 外观性状 ]:
淡黄薄片

[ 折射率 ]:
1.553

[ 储存条件 ]:
室温

6-十二酰基-N,N-二甲基-2-萘胺(Laurdan)MSDS

详细MSDS(安全技术说明书)

6-十二酰基-N,N-二甲基-2-萘胺(Laurdan)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

6-十二酰基-N,N-二甲基-2-萘胺(Laurdan)文献

Interactions of beta-blockers with model lipid membranes: molecular view of the interaction of acebutolol, oxprenolol, and propranolol with phosphatidylcholine vesicles by time-dependent fluorescence shift and molecular dynamics simulations.

Eur. J. Pharm. Biopharm. 87(3) , 559-69, (2014)

Since pharmacokinetic and pharmacodynamic activities of drugs are often related to their interactions with biomembranes, it is of high interest to establish an approach for the characterization of the...

Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties.

J. Lipid Res. 56 , 2158-71, (2015)

Cytotoxic bile acids, such as deoxycholic acid (DCA), are responsible for hepatocyte cell death during intrahepatic cholestasis. The mechanisms responsible for this effect are unclear, and recent stud...

Molecular mechanism of action of chlorogenic acid on erythrocyte and lipid membranes.

Mol. Membr. Biol. 32 , 46-54, (2015)

The high antioxidant capacity of chlorogenic acid (CGA) in respect to biological systems is commonly known, though the molecular mechanism underlying that activity is not known. The aim of the study w...

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