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(20R)-原人参二醇

(20R)-原人参二醇用途

(20R)-Protopanaxadiol 是黑参中 20(R)-ginsenoside Rg3 的三萜皂苷代谢物。(20R)-Protopanaxadiol 具有抗肿瘤活性和细胞毒性,能有效抑制幽门螺杆菌的生长。

(20R)-原人参二醇名称

[ CAS 号 ]:
7755-01-3

[ 中文名 ]:
原人参二醇

[ 英文名 ]:
(20R)-Protopanaxdiol

[中文别名 ]:

原人参二醇(PPD)/ 20(R)-原人参二醇皂苷

[英文别名 ]:

Protopanaxadiol
20R-Betulafolienetriol

(20R)-原人参二醇生物活性

[ 描述 ]:

(20R)-Protopanaxadiol 是黑参中 20(R)-ginsenoside Rg3 的三萜皂苷代谢物。(20R)-Protopanaxadiol 具有抗肿瘤活性和细胞毒性,能有效抑制幽门螺杆菌的生长。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Liu L, et al. Enzymatic preparation of 20(S, R)-protopanaxadiol by transformation of 20(S, R)-Rg3 from black ginseng. Phytochemistry. 2010 Sep;71(13):1514-20.

[2]. Bae EA, et al. Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull. 2002 Jan;25(1):58-63.

[3]. Hasegawa H, et al. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med. 1994 Jun;60(3):240-3.

(20R)-原人参二醇物理化学性质

[ 密度 ]:
1.036 g/cm3

[ 沸点 ]:
559.5ºC at 760 mmHg

[ 分子式 ]:
C₃₀H₅₂O₃

[ 分子量 ]:
460.73200

[ 闪点 ]:
226.1ºC

[ 精确质量 ]:
460.39200

[ PSA ]:
60.69000

[ LogP ]:
6.50060

[ 折射率 ]:
1.528

[ 储存条件 ]:
2-8°C

(20R)-原人参二醇MSDS

详细MSDS(安全技术说明书)

(20R)-原人参二醇安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

(20R)-原人参二醇文献

An integrated high resolution mass spectrometric data acquisition method for rapid screening of saponins in Panax notoginseng (Sanqi).

J. Pharm. Biomed. Anal. 109 , 184-91, (2015)

The aim of this study was to develop a convenient method without pretreatments for nontarget discovery of interested compounds. The segment and exposure strategy, coupled with two mass spectrometer da...

Integrated evaluation of malonyl ginsenosides, amino acids and polysaccharides in fresh and processed ginseng.

J. Pharm. Biomed. Anal. 107 , 89-97, (2015)

Many analytical methods have been developed to characterize ginsenosides in ginseng. Relatively less attention has been paid to the malonyl ginsenosides, amino acids and polysaccharides in various pro...

TRAIL pathway is associated with inhibition of colon cancer by protopanaxadiol.

J. Pharmacol. Sci. 127(1) , 83-91, (2015)

Among important components of American ginseng, protopanaxadiol (PPD) showed more active anticancer potential than other triterpenoid saponins. In this study, we determined the in vivo effects of PPD ...

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