(3α,5α)-3-Hydroxy-11,20-dioxopregnan-21-yl acetate-(3α,5α)-3-hy droxypregnane-11,20-dione (1:1)

名称

[ CAS 号 ]:
8067-82-1

[ 英文名 ]:
(3α,5α)-3-Hydroxy-11,20-dioxopregnan-21-yl acetate-(3α,5α)-3-hy droxypregnane-11,20-dione (1:1)

物理化学性质

[ 沸点 ]:
523.6ºC at 760 mmHg

[ 分子式 ]:
C₄₄H₆₆O₈

[ 分子量 ]:
722.99000

[ 闪点 ]:
175.1ºC

[ 精确质量 ]:
722.47600

[ PSA ]:
135.04000

[ LogP ]:
7.09160

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4158100

CAS REGISTRY NUMBER :: 8067-82-1

LAST UPDATED :: 199504

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C23-H34-O5.C21-H32-O3

MOLECULAR WEIGHT :: 723.10

WISWESSER LINE NOTATION :: L E5 B666 CVTJ A1 E1 FV1OV1 OQ &L E5 B666 CVTJ A1 E1 FV1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

REFERENCE :: PRACAK Practitioner. (Morgan-Grampian Ltd., 40 Beresford St., Woolwich, London SE18 6BQ, UK) V.1- 1868- Volume(issue)/page/year: 222,249,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 79 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 32,375,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 1,119,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: JEMAAJ Journal of the Egyptian Medical Association. (Egyptian Medical Assoc., 42, Sharia Kasr-El- Aini, Cairo, Egypt) V.11- 1928- Volume(issue)/page/year: 62,191,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: JEMAAJ Journal of the Egyptian Medical Association. (Egyptian Medical Assoc., 42, Sharia Kasr-El- Aini, Cairo, Egypt) V.11- 1928- Volume(issue)/page/year: 62,191,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 12700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam, Netherlands) V.16-18, 1975-77. Discontinued. Volume(issue)/page/year: 16,208,1975 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 35 mL/kg

SEX/DURATION :: female 9-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 1,165,1975