邻苯二甲酰亚胺
邻苯二甲酰亚胺用途
该品为染料、农药、医药、橡胶助剂等许多精细化学品的中间体,例如用于生产苯酞、邻苯二甲腈、靛蓝、杀菌剂灭菌丹、杀虫剂亚胺硫磷等等。
邻苯二甲酰亚胺名称
[ CAS 号 ]:
85-41-6
[ 中文名 ]:
邻苯二甲酰亚胺
[ 英文名 ]:
O-Phthalimide
[中文别名 ]:
[英文别名 ]:
- Phthalimide
- PHTHALYLIMIDE
- 1H-Isoindole-1,3(2H)-dione
- O-Phthalimide
- EINECS 201-603-3
- Benzoimide
- Phthalimid
- Ftalimmide
- Phenylimide
- O-PHTHALIC IMIDE
邻苯二甲酰亚胺物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
359.0±25.0 °C at 760 mmHg
[ 熔点 ]:
232-235 °C(lit.)
[ 分子式 ]:
C8H5NO2
[ 分子量 ]:
147.131
[ 闪点 ]:
170.9±23.2 °C
[ 精确质量 ]:
147.032028
[ PSA ]:
46.17000
[ LogP ]:
0.80
[ 外观性状 ]:
白色片状
[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C
[ 折射率 ]:
1.679
[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运
[ 水溶解性 ]:
<0.1 g/100 mL at 19.5 ºC
邻苯二甲酰亚胺MSDS
邻苯二甲酰亚胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TI3920000
- CHEMICAL NAME :
- Phthalimide
- CAS REGISTRY NUMBER :
- 85-41-6
- BEILSTEIN REFERENCE NO. :
- 0118522
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C8-H5-N-O2
- MOLECULAR WEIGHT :
- 147.14
- WISWESSER LINE NOTATION :
- T56 BVMVJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,23,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 20,3,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1175 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 11,149,1964 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 6200 ug/kg
- SEX/DURATION :
- female 9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- REFERENCE :
- PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 31,172,1976
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- female 9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - abortion Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- REFERENCE :
- PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 31,172,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4388 No. of Facilities: 29 (estimated) No. of Industries: 1 No. of Occupations: 22 No. of Employees: 1224 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4388 No. of Facilities: 334 (estimated) No. of Industries: 6 No. of Occupations: 18 No. of Employees: 8142 (estimated) No. of Female Employees: 1591 (estimated)
邻苯二甲酰亚胺安全信息
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危害码 (欧洲) ]:
Xi
[ 风险声明 (欧洲) ]:
R20/21/22
[ 安全声明 (欧洲) ]:
S22-S24/25
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
1
[ RTECS号 ]:
TI3920000
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2925190090
邻苯二甲酰亚胺制备
1.碳铵法将苯酐和碳酸氢铵按摩尔比1:1.2混合,经粉碎机粉碎后投入反应釜,加热约4h升至200℃,再以稍快速度升温至280-300℃。将熔融物出料至结晶,冷却固化、粉碎即得成品,收率95%以上。每吨含量为95%的邻苯二甲酰亚胺需消耗苯酐1030kg、95%碳酸氢铵660kg。 2.尿素法
邻苯二甲酰亚胺海关
[ 海关编码 ]: 2925190090
[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
邻苯二甲酰亚胺文献
Bioorg. Med. Chem. Lett. 23(1) , 287-90, (2013)
Benzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A and NK0148) have been synthesized and their anti-angiogenic activity was evaluated using ex vivo egg yo...
Phthalimido-ferrocidiphenol cyclodextrin complexes: Characterization and anticancer activity.Int. J. Pharm. 491 , 323-34, (2015)
Several ferrocenyl analogues of tamoxifen have already showed strong antiproliferative activity in experimental glioma models. Nevertheless, these compounds are very poorly soluble in water and an ada...
Azolyacetones as precursors to indoles and naphthofurans facilitated by microwave irradiation with simultaneous cooling.Molecules 14(8) , 2976-84, (2009)
Phthalimide reacted with phenacyl bromide under microwave irradiation to yield phenacyl isoindolidene-1,3-dione (3b), while 3a reacted with phenylhydrazine to yield the phenylhydrazone 4 that was read...
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区域:上海市奉贤区
价格:
¥78.0/500g
联系人:刘佳
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区域:上海市浦东新区
价格:
¥67.0/500g
¥需询单/1g
¥29.0/100g
¥需询单/1g
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区域:中山市三角镇
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¥40.0/200kg
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相关化合物
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标题:邻苯二甲酰亚胺_MSDS_用途_密度_CAS号【85-41-6】_化源网 地址:https://www.chemsrc.com/amp/cas/85-41-6_889304.html