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伊卡倍特钠

伊卡倍特钠用途

Ecabet sodium (TA-2711) 可通过抑制 ROS 的产生应用于某些临床胃肠道疾病。Ecabet sodium 可以促进幽门螺杆菌的根除。Ecabet sodium 减少细胞凋亡 (apoptosis)。

伊卡倍特钠名称

[ CAS 号 ]:
86408-72-2

[ 中文名 ]:
伊卡倍特钠

[ 英文名 ]:
Ecabet sodium

[中文别名 ]:

依卡倍特钠

[英文别名 ]:

Ecabetsodiumsalt
Gastrom
12-Sulfodehydroabietic acid monosodium salt
ta-2711

伊卡倍特钠生物活性

[ 描述 ]:

Ecabet sodium (TA-2711) 可通过抑制 ROS 的产生应用于某些临床胃肠道疾病。Ecabet sodium 可以促进幽门螺杆菌的根除。Ecabet sodium 减少细胞凋亡 (apoptosis)。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

ROS production; Bacterial[1]; Apoptosis[2]

[参考文献]

[1]. Wang Y, et al. Efficacy and safety of ecabet sodium as an adjuvant therapy for Helicobacter pylori eradication: a systematic review and meta-analysis. Helicobacter. 2014 Oct;19(5):372-81.

[2]. Rah YC, et al. Ecabet sodium alleviates neomycin-induced hair cell damage. Free Radic Biol Med. 2015 Dec;89:1176-83.

伊卡倍特钠物理化学性质

[ 密度 ]:
1.241 g/cm3

[ 分子式 ]:
C₂₀H₂₇NaO₅S

[ 分子量 ]:
402.480

[ 精确质量 ]:
402.147675

[ PSA ]:
102.88000

[ LogP ]:
4.88980

[ 折射率 ]:
1.562

[ 储存条件 ]:
室温，干燥

伊卡倍特钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SF7312000

CHEMICAL NAME :: 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-meth ylethyl)- 6-sulfo-, (1R-(1-alpha,4a-beta,10a-alpha))-, monosodium salt

CAS REGISTRY NUMBER :: 86408-72-2

LAST UPDATED :: 199603

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H28-O5-S.Na

MOLECULAR WEIGHT :: 403.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4529602 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 11 gm/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 25,941,1991

伊卡倍特钠

伊卡倍特钠用途

伊卡倍特钠名称

伊卡倍特钠生物活性

伊卡倍特钠物理化学性质

伊卡倍特钠毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

伊卡倍特钠安全信息

伊卡倍特钠合成路线

详细合成路线

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