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5'-二磷酸尿嘧啶核苷-N-乙酰半乳糖胺二钠盐

用途

UDP-GlcNAc Disodium Salt 是 O-GlcNAc 转移酶 (OGT) 的供体底物。

名称

[ CAS 号 ]:
91183-98-1

[ 中文名 ]:
UDP-N-乙酰半乳糖胺二钠盐

[ 英文名 ]:
UDP-α-D-N-Acetylglucosamine Disodium Salt

[中文别名 ]:

[英文别名 ]:

URIDINE 5-DIPHOSPHO-N-ACETYLGLUCOSAMINE
MFCD00799985
UDPAG SODIUM SALT
UDP-GlcNAc disodium salt
EINECS 293-820-5
UDP-A-D-N-ACETYL-GLUCOSAMINE
UDPAG
UDP-GLCNAC,2NA
UDP-GLCNAC,NA2
UDP-N-ACETYLGLUCOSAMINE DISODIUM SALT

生物活性

[ 描述 ]:

UDP-GlcNAc Disodium Salt 是 O-GlcNAc 转移酶 (OGT) 的供体底物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[体外研究]

OGT是在CAZY(Carbohydrate-Active enZYme)数据库中分配给GT41家族的核质糖基转移酶(尿苷二磷酸-N-乙酰葡糖胺：多肽β-N-乙酰葡糖胺基转移酶或O-GlcNAc转移酶)。使用UDP-GlcNAc二钠盐(UDP-GlcNAc)作为供体底物,这种酶通过在主要限制在细胞质和细胞核内的受体底物上添加独特的N-乙酰葡糖胺残基来修饰数千种蛋白质[1]。

[参考文献]

[1]. Lefebvre T, et al. Antibodies and activity measurements for the detection of O-GlcNAc transferase and assay of its substrate, UDP-GlcNAc. Methods Mol Biol. 2013;1022:147-59.

[相关活性小分子]

物理化学性质

[ 分子式 ]:
C₁₇H₂₅N₃Na₂O₁₇P₂

[ 分子量 ]:
651.31700

[ 精确质量 ]:
651.04500

[ PSA ]:
331.14000

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
−20°C

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
22-26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
29349990

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文献

Transporter-mediated uptake of UDP-glucuronic acid by human liver microsomes: assay conditions, kinetics, and inhibition.

Drug Metab. Dispos. 43(1) , 147-53, (2014)

This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake...

Enhanced transfer of a photocross-linking N-acetylglucosamine (GlcNAc) analog by an O-GlcNAc transferase mutant with converted substrate specificity.

J. Biol. Chem. 290 , 22638-48, (2015)

O-Linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification of proteins in multicellular organisms. O-GlcNAc modification is catalyzed by the O-GlcNAc transferase (OGT), which trans...

A new antibiotic kills pathogens without detectable resistance.

Nature 517(7535) , 455-9, (2015)

Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were produced by screening soil microorganisms...

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