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Neurodazine

Neurodazine用途

Neurodazine 是一种咪唑类小分子,是多能干细胞神经发生的促进剂,通过激活 Wnt 和 Shh 信号通路促进神经发生。Neurodazine 选择性抑制 P19 细胞的星形胶质细胞分化。

Neurodazine名称

[ CAS 号 ]:
937807-66-4

[ 英文名 ]:
Neurodazine

[英文别名 ]:

Neurodazine

Neurodazine生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 干细胞及 Wnt 通路 >> Hedgehog

信号通路 >> 干细胞及 Wnt 通路 >> Wnt信号

[参考文献]

[1]. Kim GH, et al. Imidazole-based small molecules that promote neurogenesis in pluripotent cells. Angew Chem Int Ed Engl. 2014 Aug 25;53(35):9271-4.

[2]. Halder D, et al. Synthetic small molecules that induce neuronal differentiation in neuroblastoma and fibroblast cells. Mol Biosyst. 2015 Oct;11(10):2727-37.

Neurodazine物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
669.0±55.0 °C at 760 mmHg

[ 分子式 ]:
C₂₇H₂₁ClN₂O₃

[ 分子量 ]:
460.952

[ 闪点 ]:
358.4±31.5 °C

[ 精确质量 ]:
460.155365

[ PSA ]:
56.37000

[ LogP ]:
6.42

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.613

[ 储存条件 ]:
-20°C，密闭，干燥

Neurodazine安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H318-H413

[ 警示性声明 ]:
P280-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

Neurodazine文献

Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease.

Front. Endocrinol. (Lausanne.) 2 , 117, (2011)

The proliferative pool and regenerative potential of neural stem cells diminishes with age, a phenomenon that may be exacerbated in prodromal and mild Alzheimer's disease (AD) brains. In parallel, the...

Role of ciliary neurotrophic factor in the proliferation and differentiation of neural stem cells.

J. Alzheimers Dis. 37(3) , 587-92, (2013)

Ciliary neurotrophic factor (CNTF) is a pleiotropic cytokine that has been fully studied for its structure, receptor, and signaling pathways and its multiplex effects on neural system, skeletal muscle...

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