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Quinelorane dihydrochloride

Quinelorane dihydrochloride用途

盐酸奎尼洛兰(LY163502)是一种有效的多巴胺D3/D2受体激动剂。奎尼洛兰具有神经和精神疾病研究的潜力[1][2]。

Quinelorane dihydrochloride名称

[ CAS 号 ]:
97548-97-5

[ 英文名 ]:
Quinelorane hydrochloride

[英文别名 ]:

Quinelorane HCl
Quinelorane dihydrochloride
LY-163,502
Quinerlorane hydrochloride

Quinelorane dihydrochloride生物活性

[ 描述 ]:

盐酸奎尼洛兰(LY163502)是一种有效的多巴胺D3/D2受体激动剂。奎尼洛兰具有神经和精神疾病研究的潜力[1][2]。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[ 靶点 ]

D2 Receptor

D3 Receptor

[体内研究]

盐酸喹诺醚(LY163502；0.003,0.01 mg/kg；s.c.)可减少GABA外流,对雄性Wistar大鼠(300 g)有显著影响,为0.01 mg/kg,而非0.003 mg/kg[1]。盐酸奎尼洛兰(0.032,0.32,3.2,5.6 mg/kg；IP)显著且剂量依赖性地增加Sprague-Dawley大鼠的运动活性。没有性别和性别互动的主要影响[1]。盐酸喹诺醚显著降低雄性和雌性近交FVB/NJ、BALB/cJ、BALB/cByJ、C57BL/6J、Swiss Webster、A/J、DBA/2J、129S1/SvImJ和129S6/SvEvTac小鼠的活性[1]。

[参考文献]

[1]. Ying Qu, et al. Quinelorane, a dopamine D3/D2 receptor agonist, reduces prepulse inhibition of startle and ventral pallidal GABA efflux: time course studies. Pharmacol Biochem Behav. 2008 Oct;90(4):686-90.

[2]. Morgane Thomsen, et al. Psychomotor stimulation by dopamine D₁-like but not D₂-like agonists in most mouse strains. Exp Clin Psychopharmacol. 2011 Oct;19(5):342-60.

Quinelorane dihydrochloride物理化学性质

[ 沸点 ]:
438.5ºC at 760 mmHg

[ 分子式 ]:
C₁₄H₂₄Cl₂N₄

[ 分子量 ]:
319.27300

[ 闪点 ]:
219ºC

[ 精确质量 ]:
318.13800

[ PSA ]:
55.04000

[ LogP ]:
3.77110

Quinelorane dihydrochloride安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

Quinelorane dihydrochloride文献

Effects of the selective dopaminergic D2 agonist quinelorane on the activity of dopaminergic and noradrenergic neurons projecting to the diencephalon of the rat.

J. Pharmacol. Exp. Ther. 268 , 645, (1994)

The purpose of the present study was to characterize dopaminergic D2 receptor-mediated regulation of catecholaminergic neurons in the diencephalon by examining the acute effects of the potent and sele...

Effects of LY163502, a D2 dopaminergic agonist, on the sexual behavior of male rats.

Pharmacol. Biochem. Behav. 43 , 1087, (1992)

LY163502, a selective D2 receptor agonist, has been reported to stimulate sexual behavior in both copulating and noncopulating male rats. Three experiments were conducted to further characterize the r...

Oscillation of interspike interval length in substantia nigra dopamine neurons: effects of nicotine and the dopaminergic D2 agonist LY 163502 on electrophysiological activity.

Synapse 11 , 229, (1992)

The rates and patterns of discharge activity exhibited by 16 spontaneously active substantia nigra pars compacta dopamine neurons were studied in halothane-anesthetized rats using three types of quant...

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