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GSK-1482160

Names

[ CAS No. ]:
1001389-72-5

[ Name ]:
GSK-1482160

Biological Activity

[Description]:

GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1β, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

[References]

[1]. Ali Z, et al. Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects. Br J Clin Pharmacol. 2013;75(1):197-207. doi:10.1111/j.1365-2125.2012.04320.x

Chemical & Physical Properties

[ Molecular Formula ]:
C14H14ClF3N2O2

[ Molecular Weight ]:
334.72100

[ Exact Mass ]:
334.07000

[ PSA ]:
49.41000

[ LogP ]:
2.92460

Related Compounds