Simvastatin-d3

Names

[ CAS No. ]:
1002347-61-6

[ Name ]:
Simvastatin-d3

Biological Activity

[Description]:

Simvastatin-d3 is the deuterium labeled Simvastatin[1]. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)
Signaling Pathways >> Apoptosis >> Ferroptosis
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Autophagy >> Mitophagy

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Slater, E.E., et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs, 1988. 36 Suppl 3: p. 72-82.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H35D3O5

[ Molecular Weight ]:
421.58500

[ Exact Mass ]:
421.29100

[ PSA ]:
72.83000

[ LogP ]:
4.58560

Related Compounds