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Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide

Names

[ CAS No. ]:
100307-95-7

[ Name ]:
Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide

[Synonym ]:
Aaglan
Abz-ala-gly-leu-ala-nba
2-Aminobenzoylalanyl-glycyl-leucyl-alanyl-4-nitrobenzylamide
2-Aminobenzoyl-ala-gly-leu-ala-4-nitrobenzylamide
L-Alaninamide,N-(2-aminobenzoyl)-L-alanylglycyl-L-leucyl-N-((4-nitrophenyl)methyl)-,(6aS-(6aalpha,7alpha,8beta,9aalpha))

Biological Activity

[Description]:

Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Everett MJ, et, al. Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models. ACS Infect Dis. 2023 Feb 10;9(2):270-282.  

Chemical & Physical Properties

[ Density]:
1.284g/cm3

[ Boiling Point ]:
937.5ºC at 760 mmHg

[ Molecular Formula ]:
C28H37N7O7

[ Molecular Weight ]:
583.64

[ Flash Point ]:
520.8ºC

[ Exact Mass ]:
583.27500

[ PSA ]:
233.01000

[ LogP ]:
5.17060

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.595

Related Compounds