H4R antagonist 3

Names

[ Name ]:
H4R antagonist 3

[Synonym ]:
Thieno[2,3-d]pyrimidin-4-amine, 5-(4-chlorophenyl)-N-methyl-N-(1-methyl-4-piperidinyl)-

Biological Activity

[Description]:

H4R antagonist 3 (Example 18) is a histamine-4 receptor antagonist with an EC50 of ＜10 mM. H4R antagonist 3 can be used for the research of prevention of inflammatory, autoimmune, allergic, and ocular diseases[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

EC50: ＜10 mM (histamine-4 receptor)[1]

[References]

[1]. Allen J. Borchardt, et al. Aminopyrimidine inhibitors of histamine receptors for the treatment of disease. Patent US20100063047A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₁ClN₄S

[ Molecular Weight ]:
372.91