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GSK 1562590 hydrochloride

Names

[ CAS No. ]:
1003878-07-6

[ Name ]:
GSK 1562590 hydrochloride

[Synonym ]:
4H-1,4-Benzoxazine-4-acetamide, N-[(1R)-1-[3'-(aminocarbonyl)[1,1'-biphenyl]-4-yl]-2-(1-pyrrolidinyl)ethyl]-6,7-dichloro-2,3-dihydro-N-methyl-3-oxo-, hydrochloride (1:1)
4'-[(1R)-1-{[(6,7-Dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino}-2-(1-pyrrolidinyl)ethyl]-3-biphenylcarboxamide hydrochloride (1:1)

Biological Activity

[Description]:

GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT), with pKis of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Urotensin Receptor

[References]

[1]. Behm DJ, et, al. GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo. Br J Pharmacol. 2010 Sep;161(1):207-28.  

Chemical & Physical Properties

[ Molecular Formula ]:
C30H31Cl3N4O4

[ Molecular Weight ]:
617.95

[ Exact Mass ]:
616.141113

Related Compounds