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Entadamide A

Names

[ CAS No. ]:
100477-88-1

[ Name ]:
Entadamide A

[Synonym ]:
entadamide A
2-Propenamide,n-(2-hydroxyethyl)-3-(methylthio)-,(E)
N-(2-Hydroxyethyl)-3-methylthiopropenamide

Biological Activity

[Description]:

Entadamide A (compound 1) is a tryptophan derivative. Entadamide A prevents tryptophan depletion by inhibiting indoleamine 2, 3-dioxygenase (IDO), thereby inhibiting HIV replication. Entadamide A can be used in drug and neuropsychiatric studies of redesivir [1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[References]

[1]. Nzowa LK, et al. Two new tryptophan derivatives from the seed kernels of Entada rheedei: effects on cell viability and HIV infectivity. Fitoterapia. 2013 Jun;87:37-42.  

Chemical & Physical Properties

[ Density]:
1.163g/cm3

[ Boiling Point ]:
379.7ºC at 760mmHg

[ Molecular Formula ]:
C6H11NO2S

[ Molecular Weight ]:
161.22

[ Flash Point ]:
183.4ºC

[ Exact Mass ]:
161.05100

[ PSA ]:
74.63000

[ LogP ]:
0.36250

[ Vapour Pressure ]:
2.53E-07mmHg at 25°C

[ Index of Refraction ]:
1.533

Related Compounds