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MMBO

Names

[ CAS No. ]:
1005203-15-5

[ Name ]:
MMBO

[Synonym ]:
1,3,4-Oxadiazole, 2-methyl-5-[3-[4-[(S)-(1S)-methylsulfinyl]phenyl]-5-benzofuranyl]-
2-Methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole

Biological Activity

[Description]:

MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively; inhibits tau phosphorylation in primary neural cell culture and also in normal mouse brain, significantly decreases hippocampal tau phosphorylation at GSK-3 sites in transgenic mouse model of AD; suppresses tau pathology as assessed by AT8-immunoreactivity without affecting amyloid β pathology, significantly improves memory and cognitive deficits in AD models.

[References]

References 1. Onishi T, et al. J Neurochem. 2011 Dec;119(6):1330-40. View Related Products by Target GSK-3

Chemical & Physical Properties

[ Density]:
1.4±0.0 g/cm3

[ Boiling Point ]:
579.0±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H14N2O3S

[ Molecular Weight ]:
338.380

[ Flash Point ]:
304.0±0.0 °C

[ Exact Mass ]:
338.073000

[ LogP ]:
2.27

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.713

Related Compounds