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SARS-CoV-2 nsp13-IN-1

Names

[ CAS No. ]:
1005304-44-8

[ Name ]:
SARS-CoV-2 nsp13-IN-1

Biological Activity

[Description]:

SARS-CoV-2 nsp13-IN-1 (compound C1) is a potent nsp13 (non-structural protein 13) inhibitor. SARS-CoV-2 nsp13-IN-1 only inhibits nsp13 ssDNA+ ATPase, with an IC50 of 6 μM. SARS-CoV-2 nsp13-IN-1 does not inhibit ssDNA- ATPase. SARS-CoV-2 nsp13-IN-1 can be used for COVID-19 research[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

IC50: 6 ± 0.5 μM (nsp13 ssDNA+ ATPase)[1]


[References]

[1]. Yazdi AK, et al. Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors. ACS Infect Dis. 2022 Jul 13.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H20N4O2

[ Molecular Weight ]:
432.47

Related Compounds