CLK inhibitor 2
Names
[ CAS No. ]:
1005776-20-4
[ Name ]:
CLK inhibitor 2
Biological Activity
[Description]:
A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3; inhibits phospho-SRSF4 in MDA-MB-468 cells, induces alternative splicing of the S6K pre-mRNA at 1.1-3.3 uM, exhibits growth inhibitory activity with GI50 of 3.0 uM, through splicing alterations in genes involved in growth and survival.
[References]
References 1. Araki S, et al. PLoS One. 2015 Jan 12;10(1):e0116929. 2. Shi Y, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):406-412. View Related Products by Target Cdc2-like Kinase (CLK)
Chemical & Physical Properties
[ Molecular Formula ]:
C20H20N6O
[ Molecular Weight ]:
360.421