GSK-1521498

Names

[ CAS No. ]:
1007573-18-3

[ Name ]:
GSK-1521498

[Synonym ]:
unii-w0utb622gk
GSK-1521498

Biological Activity

[Description]:

GSK1521498 free base is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 free base is being used for the treatment of disorders of compulsive consumption of food, alcohol, and drugs[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[Target]

μ-opioid receptor[1]


[References]

[1]. Giuliano C, et al. The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking. Neuropsychopharmacology. 2015 Dec;40(13):2981-92.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H20F2N4

[ Molecular Weight ]:
326.34300

[ Exact Mass ]:
326.13400

[ PSA ]:
53.60000

[ LogP ]:
3.39780

Related Compounds