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cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat)

Names

[ CAS No. ]:
100853-58-5

[ Name ]:
cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat)

[Synonym ]:
PKI (5-22),AMIDE
CAMP-DEPENDENT PROTEIN KINASE INHIBITOR (5-22) AMIDE
PKI-a (5-22) aMide (huMan,Mouse,rabbit,rat),Wiptide
cAMP-Dependent Protein Kinase Inhibitor (5-22),amide,Wiptide
WIPTIDE
PROTEIN KINASE A INHIBITOR (5-22) AMIDE
TTYADFIASGRTGRRNAI-NH2
CAMP DEPENDENT PK INHIBITOR (5-22) AMIDE
PKA INHIBITOR (5-22) AMIDE
THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2
THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-HIS-ASP: TTYADFIASGRTGRRNAIHD

Biological Activity

[Description]:

PKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). PKI(5-22)amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors[1][2].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA
Signaling Pathways >> Stem Cell/Wnt >> PKA
Research Areas >> Neurological Disease

[In Vitro]

PKI(5-22)amide (1 μM; 1 min) fails to block CRF1 receptor (100 nM; 30 min) desensitization in Y-79 cells permeabilized with Streptolysin O (HY-135416)[1].

[References]

[1]. Dautzenberg FM, et al. GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation. Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R935-46.  

[2]. Reed J, et al. Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase. Biochem J. 1989 Dec 1;264(2):371-80.  

Chemical & Physical Properties

[ Molecular Formula ]:
C84H137N29O26

[ Molecular Weight ]:
1969.17000

[ Exact Mass ]:
1968.03000

[ PSA ]:
931.05000

Related Compounds