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HZ-1157

Names

[ CAS No. ]:
1009734-33-1

[ Name ]:
HZ-1157

[Synonym ]:
2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)-
5-tert-butoxy-2,4-diaminoquinazoline
5-tert-butoxyquinazoline-2,4-diamine
HZ-1157
5-[(2-Methyl-2-propanyl)oxy]-2,4-quinazolinediamine

Biological Activity

[Description]:

HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> HCV Protease
Research Areas >> Inflammation/Immunology

[Target]

IC50: 1.0 μmol/L (HCV NS3/4A protease)[2].


[In Vitro]

HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others[1][2]. Cell Viability Assay[2]. Cell Line: HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others. Concentration: 0-10 μmol/L. Incubation Time: 72 h. Result: Inhibited HCV infection in vitro with an IC50 of 0.82 μmol/L.

[References]

[1]. Ye Yu, et al. Discovering Novel anti-HCV Compounds With Inhibitory Activities Toward HCV NS3/4A Protease. Acta Pharmacol Sin. 2014 Aug;35(8):1074-81.

[2]. Bo Chao, et al. Discovery and Optimization of 2,4-diaminoquinazoline Derivatives as a New Class of Potent Dengue Virus Inhibitors. J Med Chem . 2012 Apr 12;55(7):3135-43.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
471.6±53.0 °C at 760 mmHg

[ Molecular Formula ]:
C12H16N4O

[ Molecular Weight ]:
232.282

[ Flash Point ]:
239.0±30.9 °C

[ Exact Mass ]:
232.132416

[ PSA ]:
87.05000

[ LogP ]:
2.10

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.658

[ Storage condition ]:
-20℃

Related Compounds