Hexyl cinnamaldehyde

Names

[ CAS No. ]:
101-86-0

[ Name ]:
Hexyl cinnamaldehyde

[Synonym ]:
EINECS 202-983-3
2-Hexyl-3-phenyl-2-propenal
Octanal, 2-(phenylmethylene)-, (2E)-
α-hexyl cinnamaldehyde
JASMONAL H
α-Hexylcinnamic aldehyde
MFCD00006989
(2E)-2-Benzylideneoctanal
α-Hexylcinnamaldehyde
2-hexyl-3-phenylpropenal
FEMA 2569
Hexyl cinnamal
A-HEXYLCINNAMALDEHYDE
HCA
Hexyl cinnamaldehyde
(2E)-2-(phenylmethylidene)octanal
3-phenyl-2-hexylprop-2-enal
Cinnamaldehyde, α-hexyl-
2-Benzylideneoctanal
hexyl cinnamic aldehyde
HEXYLCINNAMALDEHYDE
alpha-hexylcinnamaldehyde
2-Hexyl-3-phenylacrylaldehyde
Octanal, 2- (phenylmethylene)-
jasminolene

Biological Activity

[Description]:

α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Maria Grazia Sarpietro, et al. Interaction of α-Hexylcinnamaldehyde with a Biomembrane Model: A Possible MDR Reversal Mechanism. J Nat Prod. 2015 May 22;78(5):1154-9.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
308.1±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₀O

[ Molecular Weight ]:
216.319

[ Flash Point ]:
140.5±14.6 °C

[ Exact Mass ]:
216.151413

[ PSA ]:
17.07000

[ LogP ]:
5.33

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.530

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD6560000

CHEMICAL NAME :: Cinnamaldehyde, alpha-hexyl-

CAS REGISTRY NUMBER :: 101-86-0

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C15-H20-O

MOLECULAR WEIGHT :: 216.35

WISWESSER LINE NOTATION :: VHY6&U1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,915,1974

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,915,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(6),86,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6658 No. of Facilities: 2796 (estimated) No. of Industries: 11 No. of Occupations: 19 No. of Employees: 46014 (estimated) No. of Female Employees: 25863 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S36

[ RIDADR ]:
UN 3265 8/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
GD6560000

[ HS Code ]:
2912299000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2912299000

[ Summary ]:
2912299000. other cyclic aldehydes without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Natural ingredients based cosmetics. Content of selected fragrance sensitizers.

Contact Dermatitis 34(6) , 423-6, (1996)

In the present study, we have investigated 42 cosmetic products based on natural ingredients for content of 11 fragrance substances: geraniol, hydroxycitronellal, eugenol, isoeugenol, cinnamic aldehyd...

Evaluation of an ex vivo murine local lymph node assay: multiple endpoint comparison.

J. Appl. Toxicol. 26(4) , 333-40, (2006)

The local lymph node assay (LLNA) is used to assess the skin sensitization potential of chemicals. In the standard assay, mice are treated topically on the dorsum of both ears with test substance for ...

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Contact Dermatitis 52(4) , 207-15, (2005)

The currently used 8% fragrance mix (FM I) does not identify all patients with a positive history of adverse reactions to fragrances. A new FM II with 6 frequently used chemicals was evaluated in 1701...